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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-3-26
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pubmed:abstractText |
Focal cerebral ischemia causes microvessel matrix degradation and generates proteases known to degrade this matrix. However, proof that the proteases generated do indeed degrade vascular matrix is lacking. Here we demonstrate that active proteases derived from ischemic tissue after middle cerebral artery occlusion (MCAO) and transferred to normal tissue can degrade vascular matrix.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
998-1004
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:15001799-Animals,
pubmed-meshheading:15001799-Brain Ischemia,
pubmed-meshheading:15001799-Cerebral Cortex,
pubmed-meshheading:15001799-Cysteine Endopeptidases,
pubmed-meshheading:15001799-Endopeptidases,
pubmed-meshheading:15001799-Enzyme Activation,
pubmed-meshheading:15001799-Extracellular Matrix,
pubmed-meshheading:15001799-Heparan Sulfate Proteoglycans,
pubmed-meshheading:15001799-Immunohistochemistry,
pubmed-meshheading:15001799-Infarction, Middle Cerebral Artery,
pubmed-meshheading:15001799-Male,
pubmed-meshheading:15001799-Matrix Metalloproteinases,
pubmed-meshheading:15001799-Microcirculation,
pubmed-meshheading:15001799-Papio
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pubmed:year |
2004
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pubmed:articleTitle |
Focal cerebral ischemia induces active proteases that degrade microvascular matrix.
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pubmed:affiliation |
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, Calif 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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