Linked Life Data

14998868

Source:http://linkedlifedata.com/resource/pubmed/id/14998868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-3-4
pubmed:abstractText
Concepts of mental disorder, and of the causal processes leading to disorder, have undergone radical changes over recent decades. Genetic findings, for example, have shown that (1) many conditions develop on the basis of a dimensional genetic liability; (2) the boundaries of some conditions extend much more broadly than indicated by the traditional diagnostic categories; and (3) there is substantial overlap between conditions previously thought to be distinctively different. On the other hand, genetic findings have also provided support for the validity of some diagnostic distinctions. Early molecular genetic research was conceptualized on the basis of the expectation that there would be disease-specific genes "for" schizophrenia, bipolar disorder, and the like. It has become apparent that, at best, this constitutes a misleading oversimplification. Almost all mental disorders (in childhood and adult life) have a multifactorial origin, and the genes are likely to operate through a range of direct and indirect routes. Gene-environment correlations and interactions are important, and there is a biological substrate for individual differences in responses to psychosocial stress and adversity, as well as for the effects of such stress and adversity on the organism. The empirical basis for these changes in concepts is reviewed, and the implications for clinical science and practice are considered.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
1008
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-21
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Categories, dimensions, and the mental health of children and adolescents.
pubmed:affiliation
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom. j.wickham@iop.kcl.ac.uk
pubmed:publicationType
Journal Article