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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-3-4
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pubmed:abstractText |
The oncogene c-maf is translocated in approximately 5%-10% of multiple myelomas. Unexpectedly, we observed c-maf expression in myeloma cell lines lacking c-maf translocations and in 50% of multiple myeloma bone marrow samples. By gene expression profiling, we identified three c-maf target genes: cyclin D2, integrin beta7, and CCR1. c-maf transactivated the cyclin D2 promoter and enhanced myeloma proliferation, whereas dominant inhibition of c-maf blocked tumor formation in immunodeficient mice. c-maf-driven expression of integrin beta7 enhanced myeloma adhesion to bone marrow stroma and increased production of VEGF. We propose that c-maf transforms plasma cells by stimulating cell cycle progression and by altering bone marrow stromal interactions. The frequent overexpression of c-maf in myeloma makes it an attractive target for therapeutic intervention.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCND2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Ccnd2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin beta Chains,
http://linkedlifedata.com/resource/pubmed/chemical/MAF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Maf protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-maf,
http://linkedlifedata.com/resource/pubmed/chemical/SNF1-related protein kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/integrin beta7
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1535-6108
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14998494-Animals,
pubmed-meshheading:14998494-Bone Marrow,
pubmed-meshheading:14998494-Cadherins,
pubmed-meshheading:14998494-Cell Adhesion,
pubmed-meshheading:14998494-Cyclin D2,
pubmed-meshheading:14998494-Cyclins,
pubmed-meshheading:14998494-DNA-Binding Proteins,
pubmed-meshheading:14998494-Gene Expression Profiling,
pubmed-meshheading:14998494-Humans,
pubmed-meshheading:14998494-Integrin beta Chains,
pubmed-meshheading:14998494-Mice,
pubmed-meshheading:14998494-Models, Animal,
pubmed-meshheading:14998494-Multiple Myeloma,
pubmed-meshheading:14998494-Neoplasms, Experimental,
pubmed-meshheading:14998494-Plasma Cells,
pubmed-meshheading:14998494-Promoter Regions, Genetic,
pubmed-meshheading:14998494-Protein-Serine-Threonine Kinases,
pubmed-meshheading:14998494-Proto-Oncogene Proteins,
pubmed-meshheading:14998494-Proto-Oncogene Proteins c-maf,
pubmed-meshheading:14998494-Stromal Cells,
pubmed-meshheading:14998494-Transplantation, Heterologous,
pubmed-meshheading:14998494-Tumor Cells, Cultured,
pubmed-meshheading:14998494-Vascular Endothelial Growth Factor A
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pubmed:year |
2004
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pubmed:articleTitle |
Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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pubmed:affiliation |
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article
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