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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-1-7
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pubmed:abstractText |
Atypical antipsychotic drugs are classically associated with lower propensity to extrapyramidal symptoms (EPS) and hyperprolactinemia than typical antipsychotic drugs. It has not been clarified why some atypical antipsychotic drugs, such as amisulpride, induce prolactin plasma concentration (PRL) elevation, but little EPS. Previous studies have found an association between striatal D2/D3 receptor occupancy and PRL in typical antipsychotic treated patients suggesting that PRL is a marker of central D2/D3 receptors blockade.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
367-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14997280-Adult,
pubmed-meshheading:14997280-Antipsychotic Agents,
pubmed-meshheading:14997280-Brain,
pubmed-meshheading:14997280-Contrast Media,
pubmed-meshheading:14997280-Drug Tolerance,
pubmed-meshheading:14997280-Female,
pubmed-meshheading:14997280-Humans,
pubmed-meshheading:14997280-Hyperprolactinemia,
pubmed-meshheading:14997280-Male,
pubmed-meshheading:14997280-Middle Aged,
pubmed-meshheading:14997280-Psychotic Disorders,
pubmed-meshheading:14997280-Receptors, Dopamine D2,
pubmed-meshheading:14997280-Receptors, Dopamine D3,
pubmed-meshheading:14997280-Schizophrenia,
pubmed-meshheading:14997280-Sulpiride,
pubmed-meshheading:14997280-Tomography, Emission-Computed, Single-Photon
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pubmed:year |
2004
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pubmed:articleTitle |
Prolactinemia is uncoupled from central D2/D3 dopamine receptor occupancy in amisulpride treated patients.
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pubmed:affiliation |
Section of Neurochemical Imaging, Institute of Psychiatry, King's College London, Denmark Hill, London, UK. r.bressan@iop.kcl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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