Source:http://linkedlifedata.com/resource/pubmed/id/14996706
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-6-21
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pubmed:abstractText |
Pretargeted radioimmunotherapy (PRIT) has the potential to increase the dose of radionuclide delivered to tumors while limiting radiation to normal tissues. The purpose of this phase 1 trial is to assess safety of this multistep approach using a novel tetrameric single-chain anti-CD20-streptavidin fusion protein (B9E9FP) as the targeting moiety in patients with B-cell non-Hodgkin lymphoma (NHL), and to characterize its pharmacokinetics and immunogenicity. All patients received B9E9FP (160 mg/m(2) or 320 mg/m(2)); either 48 or 72 hours later, a synthetic clearing agent (sCA) was administered (45 mg/m(2)) to remove circulating unbound B9E9FP. (90)Yttrium ((90)Y; 15 mCi/m(2))/(111)In (5 mCi)-DOTA-biotin was injected 24 hours later. There were 15 patients enrolled in the study. B9E9FP had a mean plasma half-life (T(1/2)) of 25 +/- 6 hours with a reduction in plasma level of more than 95% within 6 hours of sCA administration. (90)Y/(111)In-DOTA-biotin infusion resulted in rapid tumor localization and urinary excretion. The ratio of average tumor to whole-body radiation dose was 49:1. No significant hematologic toxicities were noted in 12 patients. There were 2 patients who had hematologic toxicity related to progressive disease. There were 2 complete remissions (90 and 325 days) and one partial response (297 days). B9E9FP performs well as the targeting component of PRIT with encouraging dosimetry, safety, and efficacy. A dose escalation trial of (90)Y-DOTA-biotin in this format is warranted.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-4971
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pubmed:author |
pubmed-author:AxworthyDon BDB,
pubmed-author:BreitzHazel BHB,
pubmed-author:ForeroAndresA,
pubmed-author:GhalieRichard GRG,
pubmed-author:GorisMichael LML,
pubmed-author:HankinsJordanJ,
pubmed-author:KnoxSusan JSJ,
pubmed-author:LoBuglioAlbert FAF,
pubmed-author:MeredithRuby FRF,
pubmed-author:PicozziVincent JVJ,
pubmed-author:SahuR PRP,
pubmed-author:SimsRobert BRB,
pubmed-author:VoseJulie MJM,
pubmed-author:WeidenPaul LPL
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-36
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14996706-Adult,
pubmed-meshheading:14996706-Aged,
pubmed-meshheading:14996706-Aged, 80 and over,
pubmed-meshheading:14996706-Antigens, CD20,
pubmed-meshheading:14996706-Cohort Studies,
pubmed-meshheading:14996706-Female,
pubmed-meshheading:14996706-Gamma Cameras,
pubmed-meshheading:14996706-Humans,
pubmed-meshheading:14996706-Lymphoma, B-Cell,
pubmed-meshheading:14996706-Male,
pubmed-meshheading:14996706-Middle Aged,
pubmed-meshheading:14996706-Pilot Projects,
pubmed-meshheading:14996706-Radioimmunotherapy,
pubmed-meshheading:14996706-Recombinant Fusion Proteins,
pubmed-meshheading:14996706-Tissue Distribution
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pubmed:year |
2004
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pubmed:articleTitle |
Phase 1 trial of a novel anti-CD20 fusion protein in pretargeted radioimmunotherapy for B-cell non-Hodgkin lymphoma.
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pubmed:affiliation |
University of Alabama at Birmingham Comprehensive Cancer Center, 35294-3300, USA. andres.forero@ccc.uab.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Multicenter Study,
Clinical Trial, Phase I
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