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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-3-2
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pubmed:abstractText |
Tumors express embryonic carbohydrate antigens called tumor-associated carbohydrate antigens (TACA). TACA-containing glycopeptides are appealing cytotoxic T cell (CTL)-based vaccines to prevent or treat cancer because the same sugar moieties are expressed in a variety of tumors, rendering a vaccination strategy applicable in a large population. Here we demonstrate that by using glycopeptides with high affinity for the major histocompatibility complex and glycosylated in a position corresponding to a critical T cell receptor (TcR) contact, it is possible to induce anti-TACA CTL in vivo. In the current study we show that designer glycopeptides containing the Thomsen-Freidenreich (TF) antigen (beta-Gal-[1-->3]-alpha-GalNAc-O-serine) are immunogenic in vivo and generate TF-specific CTL capable of recognizing a variety of tumor cells in vitro including a MUC1-expressing tumor. The fine specificity of the TF-specific CTL repertoire indicates that the TcR recognize the glycosylated amino acid residue together with TF in a conventional major histocompatibility complex class I-restricted fashion. These results have high potential for immunotherapy against a broad range of tumors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-10092793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-10429679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-11244028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-11248807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-11429607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-11745336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-11877472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-12103351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-12445314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-12461079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-1323877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-1540975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-1599915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-1697589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-1709722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-1727666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-1997178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-2364387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-2445486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-2461799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-2471972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-2662714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-2908846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-3360239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-3417635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-4934423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-6729450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-7540044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-7540657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-7590831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-7690810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-7694806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-7795413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-8046349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-8047072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-8093457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-8104103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-8393050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-8443822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-8595249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-8605919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-8667619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-8877380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-8985092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-8985750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-9294144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-9443411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14993254-9973386
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
199
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
707-16
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:14993254-Amino Acid Sequence,
pubmed-meshheading:14993254-Animals,
pubmed-meshheading:14993254-Antigens, Tumor-Associated, Carbohydrate,
pubmed-meshheading:14993254-Cancer Vaccines,
pubmed-meshheading:14993254-Carbohydrate Sequence,
pubmed-meshheading:14993254-Cross Reactions,
pubmed-meshheading:14993254-Drug Design,
pubmed-meshheading:14993254-Female,
pubmed-meshheading:14993254-Glycopeptides,
pubmed-meshheading:14993254-Mice,
pubmed-meshheading:14993254-Mice, Inbred C57BL,
pubmed-meshheading:14993254-Molecular Structure,
pubmed-meshheading:14993254-T-Lymphocytes, Cytotoxic
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pubmed:year |
2004
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pubmed:articleTitle |
Designer glycopeptides for cytotoxic T cell-based elimination of carcinomas.
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pubmed:affiliation |
Torrey Pines Institute for Molecular Studies, 3550 General Atomic Court, San Diego, CA 92121, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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