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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-3-16
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pubmed:abstractText |
Although Brugada syndrome revolves around reduced net depolarizing force, the electrophysiological mechanisms of its defining features (right precordial ST-segment elevation and ventricular tachyarrhythmias) remain unresolved. Two proposed mechanisms are (1) right ventricular (RV) conduction delay and (2) selective and significant RV subepicardial action potential shortening. Both mechanisms must cause disparate contractile changes: delay in RV contraction and reduction of contractile force, respectively. We aimed to establish the electrophysiological mechanism of Brugada syndrome by studying the timing and force of RV contraction.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1272-7
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pubmed:dateRevised |
2011-7-22
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pubmed:meshHeading |
pubmed-meshheading:14993143-Action Potentials,
pubmed-meshheading:14993143-Adult,
pubmed-meshheading:14993143-Anti-Arrhythmia Agents,
pubmed-meshheading:14993143-Calcium Channels, L-Type,
pubmed-meshheading:14993143-Echocardiography, Doppler,
pubmed-meshheading:14993143-Electrocardiography,
pubmed-meshheading:14993143-Female,
pubmed-meshheading:14993143-Flecainide,
pubmed-meshheading:14993143-Heart Ventricles,
pubmed-meshheading:14993143-Humans,
pubmed-meshheading:14993143-Ion Transport,
pubmed-meshheading:14993143-Male,
pubmed-meshheading:14993143-Middle Aged,
pubmed-meshheading:14993143-Models, Cardiovascular,
pubmed-meshheading:14993143-Myocardial Contraction,
pubmed-meshheading:14993143-Sodium Channels,
pubmed-meshheading:14993143-Syndrome,
pubmed-meshheading:14993143-Tachycardia, Ventricular,
pubmed-meshheading:14993143-Time Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Delay in right ventricular activation contributes to Brugada syndrome.
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pubmed:affiliation |
Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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