Linked Life Data

14992269

Source:http://linkedlifedata.com/resource/pubmed/id/14992269

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-3-2
pubmed:abstractText
It has been proposed that hypotaurine may function as an antioxidant in vivo. We investigated whether this compound can act as protective agent able to prevent damage from peroxynitrite, a strong oxidizing and nitrating agent that reacts with several biomolecules. The results showed that the compound efficiently protects tyrosine against nitration, alpha1-antiproteinase against inactivation, and human low-density lipoprotein against modification by peroxynitrite. Hypotaurine is also highly effective in inhibiting peroxynitrite-mediated nitration of tyrosine in the presence of added bicarbonate. This result suggests that hypotaurine could play an important role as protective agent under physiological conditions. Moreover, it was found that cysteine sulfinic acid, but not taurine, possesses protective properties against peroxynitrite-dependent damage similar to hypotaurine. These findings indicate that the protective effects exerted by these compounds may be attributable to the presence of the sulfinic group oxidizable into sulfonate by scavenging peroxynitrite and/or its derived species.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0364-3190
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-6
pubmed:dateRevised
2005-2-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Antioxidant properties of sulfinates: protective effect of hypotaurine on peroxynitrite-dependent damage.
pubmed:affiliation
Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Istituto di Biologia e Patologia Molecolari del CNR, Università di Roma La Sapienza, Piazzale A. Moro 5, Roma, Italy. mario.fontana@uniromal.it
pubmed:publicationType
Journal Article