|
rdf:type |
|
|
lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-3-1
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pubmed:abstractText |
Most cancer cells acquire immortal capability by telomerase activation. The human telomerase reverse transcriptase gene (hTERT) is considered to be the major determinant of the enzymatic activity of human telomerase, and the hTERT promoter contains several c-Myc binding sites that mediate hTERT transcriptional activation. Few studies have examined the role of hTERT in hepatocarcinogenesis, and the relationship between c-Myc and telomerase in human hepatocellular carcinoma tissue is unknown.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1007-9327
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
10
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
638-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14991929-Carcinoma, Hepatocellular,
pubmed-meshheading:14991929-Cell Line,
pubmed-meshheading:14991929-DNA-Binding Proteins,
pubmed-meshheading:14991929-Fibroblasts,
pubmed-meshheading:14991929-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:14991929-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:14991929-Humans,
pubmed-meshheading:14991929-Liver Neoplasms,
pubmed-meshheading:14991929-Luciferases,
pubmed-meshheading:14991929-Plasmids,
pubmed-meshheading:14991929-Promoter Regions, Genetic,
pubmed-meshheading:14991929-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:14991929-RNA, Messenger,
pubmed-meshheading:14991929-Telomerase
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pubmed:year |
2004
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|
pubmed:articleTitle |
Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma.
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|
pubmed:affiliation |
Division of General Surgery, Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan, China.
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pubmed:publicationType |
Journal Article
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