| pubmed-article:14991814 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14991814 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:14991814 | lifeskim:mentions | umls-concept:C0582587 | lld:lifeskim |
| pubmed-article:14991814 | lifeskim:mentions | umls-concept:C0206249 | lld:lifeskim |
| pubmed-article:14991814 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:14991814 | lifeskim:mentions | umls-concept:C0205202 | lld:lifeskim |
| pubmed-article:14991814 | lifeskim:mentions | umls-concept:C0961954 | lld:lifeskim |
| pubmed-article:14991814 | lifeskim:mentions | umls-concept:C1100939 | lld:lifeskim |
| pubmed-article:14991814 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14991814 | pubmed:dateCreated | 2004-3-1 | lld:pubmed |
| pubmed-article:14991814 | pubmed:abstractText | Although memory deficits have been clearly documented in patients with human immunodeficiency virus type-1 (HIV-1) infection, the physiological basis of this dysfunction is poorly understood. We focused on Tat, a viral protein released from HIV-1-infected cells and investigated its effect on spatial learning in adult mice. An intracerebroventricular injection of Tat leads to attenuation of spatial learning accompanied by suppression of long-term potentiation (LTP), the cellular basis of spatial learning, in hippocampal cornu ammonis 1 pyramidal neurons. Tat facilitates extrasynaptic but not synaptic N-methyl-D-aspartate (NMDA) receptor activity. Taken together, these data provide strong evidence that the Tat pathway underlies the development of memory dysfunction in patients with HIV-1 infection and suggest a causal relationship between Tat, the facilitation of extrasynaptic NMDA receptor activity, inhibition of LTP, and attenuation of spatial learning. | lld:pubmed |
| pubmed-article:14991814 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14991814 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14991814 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14991814 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14991814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14991814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14991814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14991814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14991814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14991814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14991814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14991814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14991814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14991814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14991814 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14991814 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14991814 | pubmed:issn | 0364-5134 | lld:pubmed |
| pubmed-article:14991814 | pubmed:author | pubmed-author:MatsushitaMas... | lld:pubmed |
| pubmed-article:14991814 | pubmed:author | pubmed-author:TomizawaKazuh... | lld:pubmed |
| pubmed-article:14991814 | pubmed:author | pubmed-author:MoriwakiAkiyo... | lld:pubmed |
| pubmed-article:14991814 | pubmed:author | pubmed-author:LiSheng-TianS... | lld:pubmed |
| pubmed-article:14991814 | pubmed:author | pubmed-author:MatsuiHidekiH | lld:pubmed |
| pubmed-article:14991814 | pubmed:author | pubmed-author:WuHai-YanHY | lld:pubmed |
| pubmed-article:14991814 | pubmed:author | pubmed-author:LuYun-FeiYF | lld:pubmed |
| pubmed-article:14991814 | pubmed:author | pubmed-author:TeradaHiroaki... | lld:pubmed |
| pubmed-article:14991814 | pubmed:author | pubmed-author:SahekiYasunor... | lld:pubmed |
| pubmed-article:14991814 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14991814 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:14991814 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14991814 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14991814 | pubmed:pagination | 362-71 | lld:pubmed |
| pubmed-article:14991814 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:14991814 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14991814 | pubmed:articleTitle | HIV-1 Tat inhibits long-term potentiation and attenuates spatial learning [corrected]. | lld:pubmed |
| pubmed-article:14991814 | pubmed:affiliation | Department of Physiology, Graduate School of Medicine and Dentistry, Okayama University, Shikata, Okayama, Japan. shiri-ns@umin.ac.jp | lld:pubmed |
| pubmed-article:14991814 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14991814 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14991814 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:14991814 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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