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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-3-1
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pubmed:abstractText |
Although memory deficits have been clearly documented in patients with human immunodeficiency virus type-1 (HIV-1) infection, the physiological basis of this dysfunction is poorly understood. We focused on Tat, a viral protein released from HIV-1-infected cells and investigated its effect on spatial learning in adult mice. An intracerebroventricular injection of Tat leads to attenuation of spatial learning accompanied by suppression of long-term potentiation (LTP), the cellular basis of spatial learning, in hippocampal cornu ammonis 1 pyramidal neurons. Tat facilitates extrasynaptic but not synaptic N-methyl-D-aspartate (NMDA) receptor activity. Taken together, these data provide strong evidence that the Tat pathway underlies the development of memory dysfunction in patients with HIV-1 infection and suggest a causal relationship between Tat, the facilitation of extrasynaptic NMDA receptor activity, inhibition of LTP, and attenuation of spatial learning.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bicuculline,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0364-5134
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
362-71
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:14991814-Animals,
pubmed-meshheading:14991814-Animals, Newborn,
pubmed-meshheading:14991814-Behavior, Animal,
pubmed-meshheading:14991814-Bicuculline,
pubmed-meshheading:14991814-Calcium,
pubmed-meshheading:14991814-Cells, Cultured,
pubmed-meshheading:14991814-Dizocilpine Maleate,
pubmed-meshheading:14991814-Drug Interactions,
pubmed-meshheading:14991814-Electric Stimulation,
pubmed-meshheading:14991814-Embryo, Mammalian,
pubmed-meshheading:14991814-Excitatory Amino Acid Agonists,
pubmed-meshheading:14991814-Excitatory Amino Acid Antagonists,
pubmed-meshheading:14991814-Excitatory Postsynaptic Potentials,
pubmed-meshheading:14991814-GABA Antagonists,
pubmed-meshheading:14991814-Gene Products, tat,
pubmed-meshheading:14991814-HIV-1,
pubmed-meshheading:14991814-Hippocampus,
pubmed-meshheading:14991814-Injections, Intraventricular,
pubmed-meshheading:14991814-Long-Term Potentiation,
pubmed-meshheading:14991814-Male,
pubmed-meshheading:14991814-Maze Learning,
pubmed-meshheading:14991814-Mice,
pubmed-meshheading:14991814-Microscopy, Confocal,
pubmed-meshheading:14991814-N-Methylaspartate,
pubmed-meshheading:14991814-Neural Conduction,
pubmed-meshheading:14991814-Neurons,
pubmed-meshheading:14991814-Patch-Clamp Techniques,
pubmed-meshheading:14991814-Peptides,
pubmed-meshheading:14991814-Spatial Behavior,
pubmed-meshheading:14991814-Time Factors,
pubmed-meshheading:14991814-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2004
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pubmed:articleTitle |
HIV-1 Tat inhibits long-term potentiation and attenuates spatial learning [corrected].
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pubmed:affiliation |
Department of Physiology, Graduate School of Medicine and Dentistry, Okayama University, Shikata, Okayama, Japan. shiri-ns@umin.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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