Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1992-9-16
pubmed:abstractText
Nickel(II) acetate (NiAcet), a soluble nickel salt known to be an effective initiator of renal epithelial tumors in adult rats, was studied for possible transplacental carcinogenicity. Pregnant F344/NCr rats were given NiAcet i.p. either once a day on day 17 (90 mumol/kg body wt; group 1) or twice on days 16 and 18 of gestation (45 mumol/kg body wt/day; group 2). Offspring of these rats were further subdivided into groups 1A and B and 2A and B, respectively. Groups 1A and 2A received ordinary tap water while groups 1B and 2B received drinking water containing 500 p.p.m. sodium barbital (NaBB) during weeks 4-85 of age. Renal cortical epithelial and renal pelvic transitional epithelial tumors occurred in male offspring given NiAcet prenatally followed by NaBB postnatally (group 1B, 15 tumors in 8/15 rats; group 2B, 10 tumors in 7/15), but not in male offspring given NiAcet only (0/32) or in controls given prenatal sodium acetate (NaAcet) only (0/15) and rarely in males given NaAcet followed by the promoter NaBB (1/15). No renal tumors occurred in females. Pituitary tumor incidence was significantly higher in offspring of both sexes given NiAcet prenatally (NaAcet controls, 4/31, both sexes combined; group 1A, 14/33, P = 0.012; group 2A, 14/31, P = 0.008). Pituitary tumors appeared much earlier in rats given NiAcet prenatally, with or without postnatal NaBB, and often were malignant by cytologic and histologic criteria including pleomorphism and invasion of adjacent structures, unlike the well-differentiated adenomas that occurred less frequently in untreated rats. These results are the first evidence that Ni(II) is a potent transplacental initiator of epithelial tumors in fetal rat kidney and a complete transplacental carcinogen for rat pituitary.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0143-3334
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1351-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:1499087-Acetic Acid, pubmed-meshheading:1499087-Acetic Acids, pubmed-meshheading:1499087-Adenoma, pubmed-meshheading:1499087-Animals, pubmed-meshheading:1499087-Barbiturates, pubmed-meshheading:1499087-Body Weight, pubmed-meshheading:1499087-Carcinoma, pubmed-meshheading:1499087-Female, pubmed-meshheading:1499087-Kidney Cortex, pubmed-meshheading:1499087-Kidney Neoplasms, pubmed-meshheading:1499087-Kidney Pelvis, pubmed-meshheading:1499087-Male, pubmed-meshheading:1499087-Maternal-Fetal Exchange, pubmed-meshheading:1499087-Papilloma, pubmed-meshheading:1499087-Pituitary Gland, Anterior, pubmed-meshheading:1499087-Pituitary Neoplasms, pubmed-meshheading:1499087-Pregnancy, pubmed-meshheading:1499087-Rats, pubmed-meshheading:1499087-Rats, Inbred F344, pubmed-meshheading:1499087-Sex Factors
pubmed:year
1992
pubmed:articleTitle
Transplacental carcinogenic effects of nickel(II) acetate in the renal cortex, renal pelvis and adenohypophysis in F344/NCr rats.
pubmed:affiliation
Biological Carcinogenesis and Development Program, PRI/DynCorp, Frederick, MD.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.