| pubmed-article:14990465 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14990465 | lifeskim:mentions | umls-concept:C0008377 | lld:lifeskim |
| pubmed-article:14990465 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
| pubmed-article:14990465 | lifeskim:mentions | umls-concept:C1959616 | lld:lifeskim |
| pubmed-article:14990465 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14990465 | pubmed:dateCreated | 2004-3-1 | lld:pubmed |
| pubmed-article:14990465 | pubmed:abstractText | It is postulated that the specific interactions between cholesterol and lipids in biological membranes are crucial in the formation of complexes leading subsequently to membrane domains (so-called rafts). These interactions are studied in molecular dynamics simulations performed on a dipalmitoylphosphatidylcholine (DPPC)-cholesterol bilayer mixture and a dilauroylphosphatidylcholine (DLPC)-cholesterol bilayer mixture, both having a cholesterol concentration of 40 mol %. Complexation of the simulated phospholipids with cholesterol is observed and visualized, exhibiting 2:1 and 1:1 stoichiometries. The most popular complex is found to be 1:1 in the case of DLPC, whereas the DPPC system carries a larger population of 2:1 complexes. This difference in the observed populations of complexes is shown to be a result of differences in packing geometry and phospholipid conformation due to the differing tail length of the two phosphatidylcholine lipids. Furthermore, aggregation of these complexes appears to form hydrogen-bonded networks in the system containing a mixture of cholesterol and DPPC. The CH...O hydrogen bond plays a crucial role in the formation of these complexes as well as the hydrogen bonded aggregates. The aggregation and extension of such a network implies a possible means by which phospholipid:cholesterol domains form. | lld:pubmed |
| pubmed-article:14990465 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14990465 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14990465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14990465 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14990465 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14990465 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:14990465 | pubmed:author | pubmed-author:PanditSagar... | lld:pubmed |
| pubmed-article:14990465 | pubmed:author | pubmed-author:BerkowitzMax... | lld:pubmed |
| pubmed-article:14990465 | pubmed:author | pubmed-author:BostickDavidD | lld:pubmed |
| pubmed-article:14990465 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14990465 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:14990465 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14990465 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14990465 | pubmed:pagination | 1345-56 | lld:pubmed |
| pubmed-article:14990465 | pubmed:dateRevised | 2010-9-21 | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:meshHeading | pubmed-meshheading:14990465... | lld:pubmed |
| pubmed-article:14990465 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14990465 | pubmed:articleTitle | Complexation of phosphatidylcholine lipids with cholesterol. | lld:pubmed |
| pubmed-article:14990465 | pubmed:affiliation | Department of Chemistry, Program in Molecular and Cellular Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA. pandit@iit.edu | lld:pubmed |
| pubmed-article:14990465 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14990465 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14990465 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14990465 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14990465 | lld:pubmed |
