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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-3-1
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pubmed:abstractText |
It is postulated that the specific interactions between cholesterol and lipids in biological membranes are crucial in the formation of complexes leading subsequently to membrane domains (so-called rafts). These interactions are studied in molecular dynamics simulations performed on a dipalmitoylphosphatidylcholine (DPPC)-cholesterol bilayer mixture and a dilauroylphosphatidylcholine (DLPC)-cholesterol bilayer mixture, both having a cholesterol concentration of 40 mol %. Complexation of the simulated phospholipids with cholesterol is observed and visualized, exhibiting 2:1 and 1:1 stoichiometries. The most popular complex is found to be 1:1 in the case of DLPC, whereas the DPPC system carries a larger population of 2:1 complexes. This difference in the observed populations of complexes is shown to be a result of differences in packing geometry and phospholipid conformation due to the differing tail length of the two phosphatidylcholine lipids. Furthermore, aggregation of these complexes appears to form hydrogen-bonded networks in the system containing a mixture of cholesterol and DPPC. The CH...O hydrogen bond plays a crucial role in the formation of these complexes as well as the hydrogen bonded aggregates. The aggregation and extension of such a network implies a possible means by which phospholipid:cholesterol domains form.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-10512828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-10653627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-10692323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-1069270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-11050164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-11099405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-11248214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-11566790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-11606290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-11694269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-11719055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-11867458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-12324406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-12381204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-12484857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-12648771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-12668428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-14581212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-19431848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-7674305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-7816812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-8842234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-8901542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-8980682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-9066260,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-9177342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14990465-9788908
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,2-Dipalmitoylphosphatidylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/1,2-linoleoylphosphatidylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid Bilayers,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Membranes, Artificial,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylcholines,
http://linkedlifedata.com/resource/pubmed/chemical/Water
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-3495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1345-56
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pubmed:dateRevised |
2010-9-21
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pubmed:meshHeading |
pubmed-meshheading:14990465-1,2-Dipalmitoylphosphatidylcholine,
pubmed-meshheading:14990465-Binding Sites,
pubmed-meshheading:14990465-Cholesterol,
pubmed-meshheading:14990465-Computer Simulation,
pubmed-meshheading:14990465-Hydrogen Bonding,
pubmed-meshheading:14990465-Lipid Bilayers,
pubmed-meshheading:14990465-Macromolecular Substances,
pubmed-meshheading:14990465-Membrane Microdomains,
pubmed-meshheading:14990465-Membranes, Artificial,
pubmed-meshheading:14990465-Models, Chemical,
pubmed-meshheading:14990465-Models, Molecular,
pubmed-meshheading:14990465-Molecular Conformation,
pubmed-meshheading:14990465-Phosphatidylcholines,
pubmed-meshheading:14990465-Water
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pubmed:year |
2004
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pubmed:articleTitle |
Complexation of phosphatidylcholine lipids with cholesterol.
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pubmed:affiliation |
Department of Chemistry, Program in Molecular and Cellular Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA. pandit@iit.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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