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pubmed-article:14988105pubmed:abstractTextPhylogenetic shadowing is a comparative genomics principle that allows for the discovery of conserved regions in sequences from multiple closely related organisms. We develop a formal probabilistic framework for combining phylogenetic shadowing with feature-based functional annotation methods. The resulting model, a generalized hidden Markov phylogeny (GHMP), applies to a variety of situations where functional regions are to be inferred from evolutionary constraints.lld:pubmed
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pubmed-article:14988105pubmed:articleTitleMultiple-sequence functional annotation and the generalized hidden Markov phylogeny.lld:pubmed
pubmed-article:14988105pubmed:affiliationDepartment of Statistics, University of California, 367 Evans Hall, Berkeley, CA 94720, USA.lld:pubmed
pubmed-article:14988105pubmed:publicationTypeJournal Articlelld:pubmed
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