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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-2-27
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pubmed:abstractText |
A new series of 4-amino-6-methylthio-1H-pyrazolo[3,4-d]pyrimidines (2a-m) bearing the 2-chloro-2-phenylethyl chain at the N1 position, has been synthesized. The affinity of these compounds for A1 adenosine receptor (A1AR) was measured. The compounds showed poor affinity. A more interesting result was obtained by 2a, 2d, 2g, which demonstrated inhibitory activity on cell proliferation of the A-431 cell line stimulated by epithelial growth factor (EGF) and on EGF receptor tyrosine kinase (EGFR-TK) phosphorylation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0223-5234
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pubmed:author |
pubmed-author:BondavalliFrancescoF,
pubmed-author:BrunoOlgaO,
pubmed-author:FossaPaolaP,
pubmed-author:LucacchiniAntonioA,
pubmed-author:ManettiFabrizioF,
pubmed-author:MartiniClaudiaC,
pubmed-author:MenozziGiuliaG,
pubmed-author:MorbidelliLuciaL,
pubmed-author:MostiLuisaL,
pubmed-author:RaniseAngeloA,
pubmed-author:SchenoneSilviaS,
pubmed-author:TrincavelliLetiziaL
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-60
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14987824-Adenosine A1 Receptor Antagonists,
pubmed-meshheading:14987824-Cell Division,
pubmed-meshheading:14987824-Cell Line, Tumor,
pubmed-meshheading:14987824-Drug Screening Assays, Antitumor,
pubmed-meshheading:14987824-Epidermal Growth Factor,
pubmed-meshheading:14987824-Humans,
pubmed-meshheading:14987824-Molecular Structure,
pubmed-meshheading:14987824-Phosphorylation,
pubmed-meshheading:14987824-Pyrimidines,
pubmed-meshheading:14987824-Receptor, Adenosine A1,
pubmed-meshheading:14987824-Receptor, Epidermal Growth Factor
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pubmed:year |
2004
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pubmed:articleTitle |
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation.
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pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Genova, viale Benedetto XV, 16132 Genoa, Italy. schensil@unige.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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