Linked Life Data

14987443

Source:http://linkedlifedata.com/resource/pubmed/id/14987443

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-2-27
pubmed:abstractText
Regulation of Ca2+ homeostasis in the extracellular space plays an important role in neuronal function. Several modeling studies and recent measurements have demonstrated that modest action potential or synaptic activity can result in a significant reduction in extracellular calcium ([Ca]o(2+)). Changes in [Ca]o(2+) can regulate intracellular signaling enzymes, such as Ca2+/calmodulin-dependent protein kinase II, and influence neuronal function at synaptic and nonsynaptic sites. The change in [Ca]o(2+) can affect several types of ion channels and neurotransmitter receptors and activate a Ca(2+)-sensitive receptor in neuronal membranes. Depletion of [Ca]o(2+) may function as an activity-dependent extracellular messenger that regulates nervous system function during development, learning, and disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1073-8584
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Extracellular calcium depletion in synaptic transmission.
pubmed:affiliation
National Institutes of Health, National Institute for Child and Human Development, Section on Nervous System Development and Plasticity, Bethesda, MD 20892, USA.
pubmed:publicationType
Journal Article, Review