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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-9-27
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pubmed:abstractText |
Matrix metalloproteinase-1 (MMP-1) plays a key role in cancer invasion and metastasis by degradation of extracellular matrix (ECM) and basement membrane barriers. The 1G/2G single nucleotide polymorphism (SNP) in the MMP-1 promoter at position -1607 bp has been reported to affect the transcriptional activity. In the light of these findings, we investigated whether this SNP in the MMP-1 promoter is associated with the development, differentiation, and progression of gastric cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0171-5216
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 Springer-Verlag
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
259-65
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14986114-Aged,
pubmed-meshheading:14986114-Case-Control Studies,
pubmed-meshheading:14986114-Cell Differentiation,
pubmed-meshheading:14986114-DNA,
pubmed-meshheading:14986114-Disease Progression,
pubmed-meshheading:14986114-Female,
pubmed-meshheading:14986114-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:14986114-Genetic Predisposition to Disease,
pubmed-meshheading:14986114-Genotype,
pubmed-meshheading:14986114-Humans,
pubmed-meshheading:14986114-Lymphatic Metastasis,
pubmed-meshheading:14986114-Male,
pubmed-meshheading:14986114-Matrix Metalloproteinase 1,
pubmed-meshheading:14986114-Neoplasm Invasiveness,
pubmed-meshheading:14986114-Neoplasm Staging,
pubmed-meshheading:14986114-Polymerase Chain Reaction,
pubmed-meshheading:14986114-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:14986114-Polymorphism, Single Nucleotide,
pubmed-meshheading:14986114-Promoter Regions, Genetic,
pubmed-meshheading:14986114-Stomach Neoplasms
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pubmed:year |
2004
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pubmed:articleTitle |
A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer.
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pubmed:affiliation |
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
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