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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-3-16
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pubmed:abstractText |
More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs. Therefore, screening for TPMT polymorphisms in a patient prior to prescribing these agents is recommended. The goal of this study was to determine a cut-off concentration of the TPMT activity assay beyond which genotyping of the TPMT gene should be performed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0031-6970
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5-10
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14985890-6-Mercaptopurine,
pubmed-meshheading:14985890-European Continental Ancestry Group,
pubmed-meshheading:14985890-Female,
pubmed-meshheading:14985890-Gene Frequency,
pubmed-meshheading:14985890-Genetic Techniques,
pubmed-meshheading:14985890-Genetic Testing,
pubmed-meshheading:14985890-Genotype,
pubmed-meshheading:14985890-Humans,
pubmed-meshheading:14985890-Male,
pubmed-meshheading:14985890-Methyltransferases,
pubmed-meshheading:14985890-Pharmacogenetics,
pubmed-meshheading:14985890-Phenotype,
pubmed-meshheading:14985890-Polymorphism, Genetic,
pubmed-meshheading:14985890-Purines,
pubmed-meshheading:14985890-ROC Curve,
pubmed-meshheading:14985890-Switzerland
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pubmed:year |
2004
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pubmed:articleTitle |
Thiopurine S-methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs.
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pubmed:affiliation |
Institute for Clinical Chemistry, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
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pubmed:publicationType |
Journal Article,
Comparative Study
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