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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1992-9-16
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pubmed:abstractText |
ALZ50-based enzyme immunoassay was used to study distribution of Alzheimer's disease-associated protein (ADAP) in postmortem brain tissues of 5 Alzheimer's disease (AD) and 5 non-Alzheimer's disease (NAD) subjects. There are at least three AD-associated proteins, including A68. Levels are higher in brain regions with severe neuronal loss in AD: frontal, temporal, hippocampal cortex, and amygdala. No significant ADAP was found in the NAD samples (from 2 age-matched-1 clinically demented-and 3 younger subjects). ADAP levels in four regions of AD brains were not correlated to neuritic plaque count in corresponding regions of matching formaldehyde-fixed hemispheres.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0895-0172
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
303-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1498582-Adult,
pubmed-meshheading:1498582-Aged,
pubmed-meshheading:1498582-Aged, 80 and over,
pubmed-meshheading:1498582-Alzheimer Disease,
pubmed-meshheading:1498582-Brain,
pubmed-meshheading:1498582-Brain Mapping,
pubmed-meshheading:1498582-Female,
pubmed-meshheading:1498582-Humans,
pubmed-meshheading:1498582-Male,
pubmed-meshheading:1498582-Middle Aged,
pubmed-meshheading:1498582-Nerve Tissue Proteins,
pubmed-meshheading:1498582-Neurofibrillary Tangles,
pubmed-meshheading:1498582-tau Proteins
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pubmed:year |
1992
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pubmed:articleTitle |
Distribution of Alzheimer's disease-associated protein (ADAP) in 10 human brains.
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pubmed:affiliation |
Diagnostics Division, Abbott Laboratories, Abbott Park, IL 60064.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|