Source:http://linkedlifedata.com/resource/pubmed/id/14985764
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6977
|
| pubmed:dateCreated |
2004-2-26
|
| pubmed:databankReference | |
| pubmed:abstractText |
Host cell barriers to the early phase of immunodeficiency virus replication explain the current distribution of these viruses among human and non-human primate species. Human immunodeficiency virus type 1 (HIV-1), the cause of acquired immunodeficiency syndrome (AIDS) in humans, efficiently enters the cells of Old World monkeys but encounters a block before reverse transcription. This species-specific restriction acts on the incoming HIV-1 capsid and is mediated by a dominant repressive factor. Here we identify TRIM5alpha, a component of cytoplasmic bodies, as the blocking factor. HIV-1 infection is restricted more efficiently by rhesus monkey TRIM5alpha than by human TRIM5alpha. The simian immunodeficiency virus, which naturally infects Old World monkeys, is less susceptible to the TRIM5alpha-mediated block than is HIV-1, and this difference in susceptibility is due to the viral capsid. The early block to HIV-1 infection in monkey cells is relieved by interference with TRIM5alpha expression. Our studies identify TRIM5alpha as a species-specific mediator of innate cellular resistance to HIV-1 and reveal host cell components that modulate the uncoating of a retroviral capsid.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1476-4687
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
26
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| pubmed:volume |
427
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
848-53
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| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:14985764-Amino Acid Sequence,
pubmed-meshheading:14985764-Animals,
pubmed-meshheading:14985764-Cell Line,
pubmed-meshheading:14985764-Cloning, Molecular,
pubmed-meshheading:14985764-Cytoplasmic Structures,
pubmed-meshheading:14985764-Disease Susceptibility,
pubmed-meshheading:14985764-Genetic Variation,
pubmed-meshheading:14985764-HIV Infections,
pubmed-meshheading:14985764-HIV-1,
pubmed-meshheading:14985764-HeLa Cells,
pubmed-meshheading:14985764-Humans,
pubmed-meshheading:14985764-Macaca mulatta,
pubmed-meshheading:14985764-Molecular Sequence Data,
pubmed-meshheading:14985764-Mutation,
pubmed-meshheading:14985764-Protein Isoforms,
pubmed-meshheading:14985764-Proteins,
pubmed-meshheading:14985764-Simian immunodeficiency virus,
pubmed-meshheading:14985764-Species Specificity,
pubmed-meshheading:14985764-Virus Replication
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.
|
| pubmed:affiliation |
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|