Source:http://linkedlifedata.com/resource/pubmed/id/14985675
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2004-4-21
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| pubmed:abstractText |
Inducible nitric oxide synthase (iNOS) is an important molecule involved in the host defense against infectious agents. iNOS is encoded by the NOS2A gene and well-defined haplotypes exist with respect to this gene. We examined whether these haplotypes were associated with the outcome of hepatitis C virus (HCV) infection in 619 Caucasian patients from seven European liver centres. We observed five major haplotypes: (-277A)+(-1026G)+(-1659C): haplotype 1; (-277G)+(-1026T)+(-1659C): haplotype 2; (-277G)+(-1026G)+(-1659C): haplotype 3; (-277G)+(-1026T)+(-1659T): haplotype 4; and (-277A)+(-1026T)+(-1659C): haplotype 5. Distributions of these haplotypes are comparable with those of previous studies. Homozygotes for haplotype 2 or those with haplotypes 2/4 were more likely than those with the 1/1 (wild type) combination to have self-limiting infections (odds ratios (OR)=3.43; 95% confidence intervals (95% CI): 1.10-8.0; P=0.0206 and OR=5.15; 95% CI: 1.32-14.32; P=0.0018, respectively). Conversely, carriage of haplotype 1 was associated with the lack of self-limiting disease (OR=0.48; 95% CI: 0.27-0.83; P=0.009). The effect was mainly among males (OR=0.41; 95% CI: 0.182-0.942; P=0.031 for males, and OR=0.55; 95% CI: 0.24-1.37; P=0.136 for women). Carriage of haplotype 1 was not associated with initial response (P=0.268) or sustained response (P>0.171). Combinations of haplotypes 1/4 were more likely to respond to interferon monotherapy in comparison of initial responders to nonresponders (OR=2.25; 95% CI: 1.05-5.68; P=0.0275).
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/NOS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II
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| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
1466-4879
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
183-7
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| pubmed:dateRevised |
2011-10-27
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| pubmed:meshHeading |
pubmed-meshheading:14985675-Adult,
pubmed-meshheading:14985675-Antiviral Agents,
pubmed-meshheading:14985675-Cohort Studies,
pubmed-meshheading:14985675-Disease Progression,
pubmed-meshheading:14985675-European Continental Ancestry Group,
pubmed-meshheading:14985675-Female,
pubmed-meshheading:14985675-Genetic Variation,
pubmed-meshheading:14985675-Genotype,
pubmed-meshheading:14985675-Haplotypes,
pubmed-meshheading:14985675-Hepacivirus,
pubmed-meshheading:14985675-Hepatitis C,
pubmed-meshheading:14985675-Homozygote,
pubmed-meshheading:14985675-Humans,
pubmed-meshheading:14985675-Interferon-alpha,
pubmed-meshheading:14985675-Male,
pubmed-meshheading:14985675-Nitric Oxide Synthase,
pubmed-meshheading:14985675-Nitric Oxide Synthase Type II,
pubmed-meshheading:14985675-Odds Ratio,
pubmed-meshheading:14985675-Retrospective Studies,
pubmed-meshheading:14985675-Viremia
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| pubmed:year |
2004
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| pubmed:articleTitle |
Inducible nitric oxide synthase gene (NOS2A) haplotypes and the outcome of hepatitis C virus infection.
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| pubmed:affiliation |
Hepatology Division, Imperial College Faculty of Medicine at St Mary's Hospital, London, UK. yeel@edc.pitt.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Multicenter Study
|