|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0024779,
umls-concept:C0035553,
umls-concept:C0039644,
umls-concept:C0058229,
umls-concept:C0596311,
umls-concept:C1167622,
umls-concept:C1260298,
umls-concept:C1330957,
umls-concept:C1552130,
umls-concept:C1707455,
umls-concept:C2346592
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2004-3-26
|
|
pubmed:abstractText |
The new antibiotic tigecycline (9-t-butylglycylamido-minocycline; GAR-936) overcomes most of the known tetracycline resistance mechanisms. Here we analyse its mode of antibiotic action by probing 70S ribosomes of Escherichia coli with dimethylsulphate (DMS) and Fe(2+)-mediated cleavage to identify binding sites of tetracycline and tigecycline.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0305-7453
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
53
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
592-9
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA.
|
|
pubmed:affiliation |
Institut für Mikrobiologie, Biochemie und Genetik, Universität Erlangen, Erlangen, Germany.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
