Source:http://linkedlifedata.com/resource/pubmed/id/14984872
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
2004-2-26
|
| pubmed:abstractText |
The identification of individuals at high risk of developing a psychotic disorder has long been a goal of clinicians because it is thought that early treatment of this group may prevent onset of the disorder. However, little is known of predictive factors of psychosis, even within a high-risk group. This study followed up 104 young people thought to be at 'ultra high risk' for schizophrenia and other psychotic disorders by virtue of having a family history of psychotic disorder combined with some functional decline or the presence of subthreshold or self-limiting psychotic symptoms. All subjects were therefore symptomatic, but not psychotic, at intake. Thirty-six subjects (34.6%) developed frank psychotic symptoms within 12 months. Measures of symptom duration, functioning, disability and psychopathology were made at intake, 6 and 12 months. Poor functioning, long duration of symptoms, high levels of depression and reduced attention were all predictors of psychosis. A combination of family history of psychosis, a recent significant decrease in functioning and recent experience of subthreshold psychotic symptoms was also predictive of psychosis. Combining highly predictive variables yielded a method of psychosis prediction at 12 months with good positive predictive value (80.8%), negative predictive value (81.8%) and specificity (92.6%) and moderate sensitivity (60.0%). Within our symptomatic high-risk group, therefore, it appears possible to identify those individuals who are at particularly high risk of developing a psychotic disorder such as schizophrenia. Given the very high PPV and low false positive rate with this two-step process, it may be justifiable to target these individuals for intensive monitoring of mental state and even low-dose neuroleptic medication or other biological and psychosocial treatments depending on clinical condition. This indicated prevention approach could be further developed and preventive strategies in the psychoses refined.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0920-9964
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
67
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
131-42
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| pubmed:dateRevised |
2010-9-2
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| pubmed:meshHeading |
pubmed-meshheading:14984872-Adolescent,
pubmed-meshheading:14984872-Adult,
pubmed-meshheading:14984872-Affective Disorders, Psychotic,
pubmed-meshheading:14984872-Behavioral Symptoms,
pubmed-meshheading:14984872-Chi-Square Distribution,
pubmed-meshheading:14984872-Depression,
pubmed-meshheading:14984872-Female,
pubmed-meshheading:14984872-Follow-Up Studies,
pubmed-meshheading:14984872-Humans,
pubmed-meshheading:14984872-Male,
pubmed-meshheading:14984872-Negativism,
pubmed-meshheading:14984872-Neuropsychological Tests,
pubmed-meshheading:14984872-Predictive Value of Tests,
pubmed-meshheading:14984872-Prospective Studies,
pubmed-meshheading:14984872-Psychiatric Status Rating Scales,
pubmed-meshheading:14984872-Psychopathology,
pubmed-meshheading:14984872-Psychotic Disorders,
pubmed-meshheading:14984872-Quality of Life,
pubmed-meshheading:14984872-Regression (Psychology),
pubmed-meshheading:14984872-Reproducibility of Results,
pubmed-meshheading:14984872-Risk Assessment,
pubmed-meshheading:14984872-Risk Factors,
pubmed-meshheading:14984872-Schizophrenia,
pubmed-meshheading:14984872-Schizophrenic Psychology,
pubmed-meshheading:14984872-Time Factors
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features.
|
| pubmed:affiliation |
Department of Psychiatry, University of Melbourne and ORYGEN Research Centre, Australia. aryung@unimelb.edu.au
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|