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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1992-9-14
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pubmed:abstractText |
To examine the effects and optimal dose of danazol on idiopathic thrombocytopenic purpura (ITP), we administered a low-medium dose to 14 patients with this disease. A low-medium dose of danazol was effective in maintaining the platelet count at a high level, even after the dose of prednisolone was reduced. A low-medium dose of danazol without other therapy was effective in 3 of 6 patients even after they had been refractory to other treatment. A low dose of danazol was also effective in some patients for whom the other regimes were not indicated. It is concluded that a low-medium dose of danazol instead of a high dose is worth trying in ITP when the patient has become refractory to other therapeutic approaches or when these are not indicated.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0925-5710
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
293-300
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1498320-Adult,
pubmed-meshheading:1498320-Aged,
pubmed-meshheading:1498320-Autoantibodies,
pubmed-meshheading:1498320-Autoimmune Diseases,
pubmed-meshheading:1498320-Blood Platelets,
pubmed-meshheading:1498320-Combined Modality Therapy,
pubmed-meshheading:1498320-Danazol,
pubmed-meshheading:1498320-Female,
pubmed-meshheading:1498320-Humans,
pubmed-meshheading:1498320-Immunoglobulin G,
pubmed-meshheading:1498320-Immunosuppression,
pubmed-meshheading:1498320-Male,
pubmed-meshheading:1498320-Middle Aged,
pubmed-meshheading:1498320-Platelet Count,
pubmed-meshheading:1498320-Prednisolone,
pubmed-meshheading:1498320-Purpura, Thrombocytopenic, Idiopathic,
pubmed-meshheading:1498320-Splenectomy,
pubmed-meshheading:1498320-Treatment Outcome
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pubmed:year |
1992
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pubmed:articleTitle |
Danazol therapy in idiopathic thrombocytopenic purpura: the efficacy of low-medium dose therapy.
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pubmed:affiliation |
Division of Internal Medicine, Shimizu Kousei Hospital, Shizuoka, Japan.
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pubmed:publicationType |
Journal Article,
Clinical Trial
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