Linked Life Data

14981906

Source:http://linkedlifedata.com/resource/pubmed/id/14981906

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6C
pubmed:dateCreated
2004-2-25
pubmed:abstractText
The expression of human beta-defensin genes in oral squamous cell carcinomas(SCCs) was demonstrated by in situ hybridization. The expression of HBD-2 was observed not only in the inflamed lesions with bacterial infection but also in the non-inflamed carcinomas themselves (evident in 15 out of 20 carcinomas). However, HBD-3 expression was found in only 4 out of 20 SCCs. In the normal oral epithelia, the expression of HBD-2 and HBD-3 was only detected in the areas adjacent to the SCCs. These results suggest that HBD-2 might play a role in SCCs, which is different from the native defensive role of these proteins. HBD-2 may lead to the death of normal keratinocytes adjacent to the SCCs, which might, in turn, indirectly assist in the multiplication of tumor cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4629-33
pubmed:dateRevised
2010-9-17
pubmed:meshHeading
pubmed:articleTitle
Different expression patterns of beta-defensins in human squamous cell carcinomas.
pubmed:affiliation
Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Dental School, 2-5-1 Shikata-cho, Okayama 700-8525, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't