Linked Life Data

14980920

Source:http://linkedlifedata.com/resource/pubmed/id/14980920

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-2-24
pubmed:abstractText
Using a randomized, double-blind protocol design, we compared a new lower-lipid emulsion of propofol (Ampofol) containing propofol 1%, soybean oil 5%, and egg lecithin 0.6% with the most commonly used formulation of propofol (Diprivan) with respect to onset of action and recovery profiles, as well as intraoperative efficacy, when administered for induction and maintenance of general anesthesia as part of a "balanced" anesthetic technique in 63 healthy outpatients. Anesthesia was induced with sufentanil 0.1 microg/kg (or fentanyl 1 microg/kg) and propofol 2 mg/kg IV and maintained with a variable-rate propofol infusion, 120-200 microg x kg(-1) x min(-1). Onset times to loss of the eyelash reflex and dropping a syringe were recorded. Severity of pain on injection, speed of induction, intraoperative hemodynamic variables, and electroencephalographic bispectral index values were assessed. Recovery times to opening eyes and orientation were noted. The results demonstrated that there were no significant differences between Ampofol and Diprivan with respect to onset times, speed of induction, anesthetic dose requirements, bispectral index values, hemodynamic variables, recovery variables, or patient satisfaction. However, the incidence of pain on injection was more frequent in the Ampofol group (26% versus 6%, P < 0.05). We conclude that Ampofol is equipotent to Diprivan with respect to its anesthetic properties but was associated with a more frequent incidence of mild pain on injection. IMPLICATIONS: The pharmacodynamic profile of a lower-lipid containing emulsion of propofol (Ampofol) was compared with Diprivan when administered for induction and maintenance of general anesthesia. This preliminary study demonstrated that the two formulations of propofol were equivalent with respect to their induction and maintenance properties. However, Ampofol was associated with a more frequent incidence of pain on injection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0003-2999
pubmed:author
pubmed:issnType
Print
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
687-91, table of contents
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:14980920-Adult, pubmed-meshheading:14980920-Aged, pubmed-meshheading:14980920-Ambulatory Surgical Procedures, pubmed-meshheading:14980920-Anesthetics, Intravenous, pubmed-meshheading:14980920-Chemistry, Pharmaceutical, pubmed-meshheading:14980920-Double-Blind Method, pubmed-meshheading:14980920-Electroencephalography, pubmed-meshheading:14980920-Emulsions, pubmed-meshheading:14980920-Excipients, pubmed-meshheading:14980920-Female, pubmed-meshheading:14980920-Hemodynamics, pubmed-meshheading:14980920-Humans, pubmed-meshheading:14980920-Lipids, pubmed-meshheading:14980920-Male, pubmed-meshheading:14980920-Middle Aged, pubmed-meshheading:14980920-Monitoring, Intraoperative, pubmed-meshheading:14980920-Otorhinolaryngologic Surgical Procedures, pubmed-meshheading:14980920-Propofol, pubmed-meshheading:14980920-Prospective Studies
pubmed:year
2004
pubmed:articleTitle
The pharmacodynamic effects of a lower-lipid emulsion of propofol: a comparison with the standard propofol emulsion.
pubmed:affiliation
Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9068, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't