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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-2-23
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pubmed:abstractText |
The developmental transcription factor SOX-4 has been shown to be highly and differentially overexpressed in primary small cell lung carcinomas (SCLC). To examine the potential of SOX-4 for broad use as a lung cancer vaccine, we have evaluated the expression of SOX-4 in a panel of primary adenocarcinoma, squamous, and large cell tumor samples as well as in a panel of established small cell and non-small cell lung carcinoma tumor cell lines. SOX-4 mRNA is shown to be overexpressed in a substantial fraction of each of these lung tumor types. To examine the immunological potential of SOX-4, we have evaluated the presence of SOX-4-specific CD4 and CD8 T cells in PBMC of healthy donors and the presence of SOX4-specific Abs in sera from SCLC patients. We demonstrate the presence of both CD4 and CD8 T cells that recognize naturally processed epitopes derived from SOX-4 as well as the presence of SOX-4-specific Abs in sera from SCLC patients, but not in sera from healthy donors. The lung tumor-specific overexpression and demonstration of a comprehensive Ag-specific immune response specific for SOX-4 support the use of this molecule in the development of whole gene-, peptide-, or protein-based vaccination strategies against lung cancer. Furthermore, the identification of naturally processed T cell and Ab epitopes from SOX-4 provides valuable tools for the development of peptide-based vaccination strategies against lung cancer as well as to monitor SOX-4-specific responses in vaccinated patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Cancer Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/High Mobility Group Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/SOX4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SOXC Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3319-27
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14978140-Amino Acid Sequence,
pubmed-meshheading:14978140-Antibodies, Neoplasm,
pubmed-meshheading:14978140-Antibody Specificity,
pubmed-meshheading:14978140-Antigen Presentation,
pubmed-meshheading:14978140-CD4-Positive T-Lymphocytes,
pubmed-meshheading:14978140-CD8-Positive T-Lymphocytes,
pubmed-meshheading:14978140-Cancer Vaccines,
pubmed-meshheading:14978140-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:14978140-Carcinoma, Small Cell,
pubmed-meshheading:14978140-Cell Line, Transformed,
pubmed-meshheading:14978140-Cell Line, Tumor,
pubmed-meshheading:14978140-Cells, Cultured,
pubmed-meshheading:14978140-Drug Evaluation, Preclinical,
pubmed-meshheading:14978140-Epitopes, T-Lymphocyte,
pubmed-meshheading:14978140-High Mobility Group Proteins,
pubmed-meshheading:14978140-Humans,
pubmed-meshheading:14978140-Leukocytes, Mononuclear,
pubmed-meshheading:14978140-Lung Neoplasms,
pubmed-meshheading:14978140-Lymphocyte Activation,
pubmed-meshheading:14978140-Molecular Sequence Data,
pubmed-meshheading:14978140-Neoplasm Proteins,
pubmed-meshheading:14978140-Peptide Fragments,
pubmed-meshheading:14978140-Polymerase Chain Reaction,
pubmed-meshheading:14978140-SOXC Transcription Factors,
pubmed-meshheading:14978140-Trans-Activators
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pubmed:year |
2004
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pubmed:articleTitle |
Molecular and immunological evaluation of the transcription factor SOX-4 as a lung tumor vaccine antigen.
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pubmed:affiliation |
Corixa, Seattle, WA 98104, USA.
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pubmed:publicationType |
Journal Article
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