|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2004-2-23
|
|
pubmed:abstractText |
FcepsilonRI expression and function is a central aspect of allergic disease. Using bone marrow-derived mouse mast cell populations, we have previously shown that the Th2 cytokine IL-4 inhibits FcepsilonRI expression and function. In the current study we show that the Th2 cytokine IL-10 has similar regulatory properties, and that it augments the inhibitory effects of IL-4. FcepsilonRI down-regulation was functionally significant, as it diminished inflammatory cytokine production and IgE-mediated FcepsilonRI up-regulation. IL-10 and IL-4 reduced FcepsilonRI beta protein expression without altering the alpha or gamma subunits. The ability of IL-4 and IL-10 to alter FcepsilonRI expression by targeting the beta-chain, a critical receptor subunit known to modulate receptor expression and signaling, suggests the presence of a Th2 cytokine-mediated homeostatic network that could serve to both initiate and limit mast cell effector function.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
pubmed-author:BaileyDaniel PDP,
pubmed-author:BoutonL AndrewLA,
pubmed-author:ChongHey JinHJ,
pubmed-author:DeMartinoRandall RRR,
pubmed-author:Fischer-StengerKristaK,
pubmed-author:GharseAnitaA,
pubmed-author:GillespieSheila RSR,
pubmed-author:GomezGregorioG,
pubmed-author:MirmonsefPariaP,
pubmed-author:OdomSandraS,
pubmed-author:RamirezCarlosC,
pubmed-author:RiveraJuanJ,
pubmed-author:RyanJohn JJJ,
pubmed-author:ShelburneChristopher PCP,
pubmed-author:ZhuJingfangJ
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
172
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3181-8
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:14978125-Adjuvants, Immunologic,
pubmed-meshheading:14978125-Animals,
pubmed-meshheading:14978125-Cells, Cultured,
pubmed-meshheading:14978125-Down-Regulation,
pubmed-meshheading:14978125-Drug Synergism,
pubmed-meshheading:14978125-Immunoglobulin E,
pubmed-meshheading:14978125-Interleukin-10,
pubmed-meshheading:14978125-Interleukin-4,
pubmed-meshheading:14978125-Mast Cells,
pubmed-meshheading:14978125-Mice,
pubmed-meshheading:14978125-Mice, Inbred BALB C,
pubmed-meshheading:14978125-Mice, Inbred C3H,
pubmed-meshheading:14978125-Mice, Inbred C57BL,
pubmed-meshheading:14978125-Mice, Knockout,
pubmed-meshheading:14978125-Protein Subunits,
pubmed-meshheading:14978125-RNA, Messenger,
pubmed-meshheading:14978125-Receptors, IgE,
pubmed-meshheading:14978125-STAT6 Transcription Factor,
pubmed-meshheading:14978125-Trans-Activators,
pubmed-meshheading:14978125-Up-Regulation
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
IL-10 inhibits Fc epsilon RI expression in mouse mast cells.
|
|
pubmed:affiliation |
Department of Biology, Virginia Commonwealth University, Richmond, VA 23284, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
