Linked Life Data

14977594

Source:http://linkedlifedata.com/resource/pubmed/id/14977594

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-2-23
pubmed:abstractText
Hypothermia is a thermoregulatory response to systemic inflammation that is often regarded as maladaptive to the host. However, rodents show regulated hypothermia (that is, a selection of cool ambient temperature) during systemic inflammation that correlates with enhanced survival, supporting an adaptive value to this response. The mechanisms regulating hypothermia are not fully understood, but cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukins (ILs) and interferon-gamma have been shown to induce or modulate hypothermia. A review of the literature suggests that TNF-alpha functions as an endogenous cryogen (i.e., induces hypothermia), whereas IL-10 modulates TNF-alpha production and/or release as a mechanism of hypothermia attenuation. IL-1beta and IL-6 are typically regarded as endogenous pyrogens, but may induce hypothermia during viral and bacterial inflammation. A role for endogenous IFN-gamma in hypothermia has not been demonstrated, but injection of this cytokine potentiates hypothermia through augmented production of other cytokines. It is clear that additional research is required in this area. Suggested areas for future research include a determination of the final mediator of hypothermia and its specific anatomical site of action as well as the role of cytokines in the regulation of hypothermia under non-inflammatory conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1877-88
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Hypothermia in systemic inflammation: role of cytokines.
pubmed:affiliation
Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760, USA. lisa.leon@na.amedd.army.mil
pubmed:publicationType
Journal Article, Review