Linked Life Data

14977541

Source:http://linkedlifedata.com/resource/pubmed/id/14977541

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-2-23
pubmed:abstractText
Diabetes leads to a marked increase in cardiovascular disease caused by atherosclerosis. Cardiovascular complications of diabetes are associated with lipid abnormalities, mainly manifested as elevated levels of triglycerides. Hydrolysis of triglycerides by lipases in the arterial wall is believed to cause increased levels of non-esterified fatty acids (NEFAs) in lesions of atherosclerosis. Recent research has shown that long-chain NEFAs have a multitude of direct effects on cell types involved in atherogenesis. Thus, some of the most common long-chained fatty acids present in triglycerides, oleic acid and linoleic acid, have been shown to induce adhesion molecule expression, cytokine expression and apoptosis in endothelial cells, to increase cholesterol uptake and reduce cholesterol efflux in macrophages, and to increase arterial smooth muscle cell proliferation and migration. Certain NEFAs liberated from triglycerides may therefore play an important role in accelerating atherosclerosis caused by diabetes by directly affecting the key cell types involved in atherogenesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1240-53
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Direct effects of long-chain non-esterified fatty acids on vascular cells and their relevance to macrovascular complications of diabetes.
pubmed:affiliation
Department of Medicine, University of Washington School of Medicine, Seattle WA 98195-7470, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't