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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1992-9-4
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pubmed:abstractText |
The nucleotide and amino acid sequences for mouse angiotensin II (AII) type 1A and 1B receptors were deduced from their complementary and genomic DNAs. Evolutionary analyses based on the nucleotide sequences of the coding region of AII type 1 receptor genes indicated that the duplication event of the type 1 gene occurred 24 +/- 2 million years ago before the divergence between the rat and mouse but after the divergence between rodents and the human/artiodactyls couple. This conclusion was consistent with the results of genomic Southern blot analyses, which revealed that the mouse and rat possess 2 similar but separate genes, whereas the bovine and human have only a single class gene.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1042-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1497638-Amino Acid Sequence,
pubmed-meshheading:1497638-Angiotensin II,
pubmed-meshheading:1497638-Animals,
pubmed-meshheading:1497638-Biological Evolution,
pubmed-meshheading:1497638-Blotting, Southern,
pubmed-meshheading:1497638-Cattle,
pubmed-meshheading:1497638-Cloning, Molecular,
pubmed-meshheading:1497638-DNA,
pubmed-meshheading:1497638-Humans,
pubmed-meshheading:1497638-Mice,
pubmed-meshheading:1497638-Molecular Sequence Data,
pubmed-meshheading:1497638-Multigene Family,
pubmed-meshheading:1497638-Phylogeny,
pubmed-meshheading:1497638-Rats,
pubmed-meshheading:1497638-Receptors, Angiotensin,
pubmed-meshheading:1497638-Restriction Mapping,
pubmed-meshheading:1497638-Sequence Homology, Nucleic Acid
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pubmed:year |
1992
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pubmed:articleTitle |
Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human).
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pubmed:affiliation |
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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