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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5663
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pubmed:dateCreated |
2004-3-5
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pubmed:abstractText |
Interferons (IFNs) are critical for protection from viral infection, but the pathways linking virus recognition to IFN induction remain poorly understood. Plasmacytoid dendritic cells produce vast amounts of IFN-alpha in response to the wild-type influenza virus. Here, we show that this requires endosomal recognition of influenza genomic RNA and signaling by means of Toll-like receptor 7 (TLR7) and MyD88. Single-stranded RNA (ssRNA) molecules of nonviral origin also induce TLR7-dependent production of inflammatory cytokines. These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myd88 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/Poly U,
http://linkedlifedata.com/resource/pubmed/chemical/Polyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 7
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
303
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1529-31
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14976261-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:14976261-Animals,
pubmed-meshheading:14976261-Antigens, Differentiation,
pubmed-meshheading:14976261-Cells, Cultured,
pubmed-meshheading:14976261-Cytokines,
pubmed-meshheading:14976261-Dendritic Cells,
pubmed-meshheading:14976261-Endocytosis,
pubmed-meshheading:14976261-Endosomes,
pubmed-meshheading:14976261-Genome, Viral,
pubmed-meshheading:14976261-Immunity, Innate,
pubmed-meshheading:14976261-Influenza A virus,
pubmed-meshheading:14976261-Interferon-alpha,
pubmed-meshheading:14976261-Ligands,
pubmed-meshheading:14976261-Membrane Glycoproteins,
pubmed-meshheading:14976261-Mice,
pubmed-meshheading:14976261-Mice, Inbred BALB C,
pubmed-meshheading:14976261-Mice, Inbred C57BL,
pubmed-meshheading:14976261-Myeloid Differentiation Factor 88,
pubmed-meshheading:14976261-Poly U,
pubmed-meshheading:14976261-Polyribonucleotides,
pubmed-meshheading:14976261-RNA,
pubmed-meshheading:14976261-RNA, Viral,
pubmed-meshheading:14976261-Receptors, Cell Surface,
pubmed-meshheading:14976261-Receptors, Immunologic,
pubmed-meshheading:14976261-Signal Transduction,
pubmed-meshheading:14976261-Toll-Like Receptor 7
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pubmed:year |
2004
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pubmed:articleTitle |
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
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pubmed:affiliation |
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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