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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2004-2-20
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pubmed:abstractText |
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the nuclear-receptor superfamily that binds to DNA with retinoid X receptors (RXRs) as PPAR-RXR heterodimers. In experimental autoimmune encephalomyelitis (EAE), the gene expression of PPAR-gamma was demonstrated in spinal cord during the course of EAE. Administration of 15-deoxy-(12,14)-prostaglandin J2 (15d-PGJ2) or 9-cis-retinoic acid (RA) alone at the onset of clinical signs of EAE reduced the severity of disease, however, their combination resulted in enhanced amelioration of disease. These results suggest that use of RXR specific ligands may be highly effective when combined with PPAR-gamma agonists in the treatment of autoimmune demyelinating diseases such as multiple sclerosis (MS).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-deoxyprostaglandin J2,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Basic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin D2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoid X Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/T-cell receptor Vbeta 8.2,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/alitretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/myelin basic protein Ac1-11(4Y)
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
148
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
116-26
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pubmed:dateRevised |
2010-9-8
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pubmed:meshHeading |
pubmed-meshheading:14975592-Analysis of Variance,
pubmed-meshheading:14975592-Animals,
pubmed-meshheading:14975592-Cells, Cultured,
pubmed-meshheading:14975592-Cytokines,
pubmed-meshheading:14975592-Dose-Response Relationship, Drug,
pubmed-meshheading:14975592-Drug Combinations,
pubmed-meshheading:14975592-Drug Interactions,
pubmed-meshheading:14975592-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:14975592-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:14975592-Immunization,
pubmed-meshheading:14975592-Immunohistochemistry,
pubmed-meshheading:14975592-Inflammation,
pubmed-meshheading:14975592-Ligands,
pubmed-meshheading:14975592-Lymph Nodes,
pubmed-meshheading:14975592-Mice,
pubmed-meshheading:14975592-Mice, Transgenic,
pubmed-meshheading:14975592-Microglia,
pubmed-meshheading:14975592-Myelin Basic Proteins,
pubmed-meshheading:14975592-Nitric Oxide,
pubmed-meshheading:14975592-Peptide Fragments,
pubmed-meshheading:14975592-Prostaglandin D2,
pubmed-meshheading:14975592-RNA, Messenger,
pubmed-meshheading:14975592-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:14975592-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:14975592-Receptors, Retinoic Acid,
pubmed-meshheading:14975592-Retinoid X Receptors,
pubmed-meshheading:14975592-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:14975592-Spleen,
pubmed-meshheading:14975592-Time Factors,
pubmed-meshheading:14975592-Transcription Factors,
pubmed-meshheading:14975592-Tretinoin
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pubmed:year |
2004
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pubmed:articleTitle |
Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.
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pubmed:affiliation |
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9036, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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