|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2004-2-20
|
|
pubmed:abstractText |
We studied the effect of HIV-1 gp160 protein and morphine on murine macrophage and human monocyte apoptosis. gp160 not only promoted murine macrophage apoptosis but also enhanced macrophage iNOS expression/NO generation. gp160 also altered macrophage bax and bcl-2 expression. Morphine enhanced (P<0.001) the effect of gp160 on macrophage apoptosis as well as iNOS expression/NO generation. Nevertheless, both morphine- and gp160-induced murine macrophage apoptosis was attenuated by nitric oxide synthase (NOS) inhibitors (L-NAME and L-NMMA). On the other hand, free radical scavengers such as superoxide dismutase (SOD), dimethylthiourea (DMTU) and catalase attenuated morphine and gp160-induced human monocyte apoptosis.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,3-dimethylthiourea,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/BAX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bax protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Catalase,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp160,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotics,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Thiourea,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0165-5728
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
148
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
86-96
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:14975589-Analysis of Variance,
pubmed-meshheading:14975589-Animals,
pubmed-meshheading:14975589-Antibodies,
pubmed-meshheading:14975589-Antigens, CD4,
pubmed-meshheading:14975589-Apoptosis,
pubmed-meshheading:14975589-Blotting, Southern,
pubmed-meshheading:14975589-Blotting, Western,
pubmed-meshheading:14975589-Caspase 3,
pubmed-meshheading:14975589-Caspases,
pubmed-meshheading:14975589-Catalase,
pubmed-meshheading:14975589-Cells, Cultured,
pubmed-meshheading:14975589-Dose-Response Relationship, Drug,
pubmed-meshheading:14975589-Drug Interactions,
pubmed-meshheading:14975589-Enzyme Inhibitors,
pubmed-meshheading:14975589-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:14975589-HIV Envelope Protein gp160,
pubmed-meshheading:14975589-Humans,
pubmed-meshheading:14975589-In Situ Nick-End Labeling,
pubmed-meshheading:14975589-Lipopolysaccharides,
pubmed-meshheading:14975589-Macrophages,
pubmed-meshheading:14975589-Mice,
pubmed-meshheading:14975589-Monocytes,
pubmed-meshheading:14975589-Morphine,
pubmed-meshheading:14975589-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:14975589-Narcotics,
pubmed-meshheading:14975589-Nitric Oxide,
pubmed-meshheading:14975589-Proto-Oncogene Proteins,
pubmed-meshheading:14975589-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:14975589-Species Specificity,
pubmed-meshheading:14975589-Superoxide Dismutase,
pubmed-meshheading:14975589-Thiourea,
pubmed-meshheading:14975589-bcl-2-Associated X Protein
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Morphine modulates HIV-1 gp160-induced murine macrophage and human monocyte apoptosis by disparate ways.
|
|
pubmed:affiliation |
Immunology and Inflammation Center, North Shore-LIJ Research Institute, The Division of Kidney Disease and Hypertension, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|
