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pubmed:abstractText |
We propose a statistical method that includes the use of longitudinal regression models and estimation procedures for adjusting for covariate effects in applying the Haseman-Elston (HE) method for linkage analysis. Our methodology, which uses the covariate adjusted trait, contains three steps: a) modelling the covariate-adjusted population means of quantitative traits through regression; b) estimating the value of covariate-adjusted quantitative traits; and c) evaluating the linkage between the adjusted trait values and the markers based on alleles shared identically by descent.
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pubmed:affiliation |
Office of Biostatistics, DECA, National Heart, Lung, and Blood Institute, 2 Rockledge Center, Bethesda, Maryland, USA. wuc@nhlbi.nih.gov
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