Source:http://linkedlifedata.com/resource/pubmed/id/14975100
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2004-2-20
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| pubmed:abstractText |
The Framingham Heart Study provides a unique source of longitudinal family data related to CVD risk factors. Age-stratified heritability estimates were obtained over three age groups (31-49 years, 50-60 years, and 61-79 years), reflecting the longitudinal nature of the data, for four quantitative traits. Age-adjusted heritability estimates were obtained at a single common time point for the same four quantitative traits. The importance of these groups is that they consist of the same individuals. The highest age-stratified heritability estimate (h2 = 0.88 (+/- 0.06)) was for height in the model adjusting for gender over all three age groups. SBP gave the lowest heritability estimate (h2 = 0.15 (+/- 0.11)) for the 70 age group in the model adjusting for gender, height, BMI, smoker, and drinker. BMI had slightly higher estimates (h2 = 0.64 (+/- 0.11)) in the 40 age group than previously published. The highest age-adjusted heritability estimate (h2 = 0.90 (+/- 0.06)) was for height in the model adjusting for gender. SBP gave the lowest heritability estimate (h2 = 0.38 (+/- 0.09)) for unadjusted model. These results indicate that some common, complex traits may vary little in their genetic architecture over time and suggest that a common set of genes may be contributing to observed variation for these longitudinally collected phenotypes.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1471-2156
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
4 Suppl 1
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
S32
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| pubmed:dateRevised |
2009-11-18
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| pubmed:meshHeading |
pubmed-meshheading:14975100-Adult,
pubmed-meshheading:14975100-Adult Children,
pubmed-meshheading:14975100-Age Factors,
pubmed-meshheading:14975100-Aged,
pubmed-meshheading:14975100-Blood Pressure,
pubmed-meshheading:14975100-Body Height,
pubmed-meshheading:14975100-Body Mass Index,
pubmed-meshheading:14975100-Body Weight,
pubmed-meshheading:14975100-Cardiovascular Diseases,
pubmed-meshheading:14975100-Cohort Studies,
pubmed-meshheading:14975100-Confidence Intervals,
pubmed-meshheading:14975100-Female,
pubmed-meshheading:14975100-Genetics, Population,
pubmed-meshheading:14975100-Humans,
pubmed-meshheading:14975100-Likelihood Functions,
pubmed-meshheading:14975100-Longitudinal Studies,
pubmed-meshheading:14975100-Male,
pubmed-meshheading:14975100-Middle Aged,
pubmed-meshheading:14975100-Quantitative Trait, Heritable,
pubmed-meshheading:14975100-Risk Factors,
pubmed-meshheading:14975100-Systole
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| pubmed:year |
2003
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| pubmed:articleTitle |
Age-stratified heritability estimation in the Framingham Heart Study families.
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| pubmed:affiliation |
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. wmbrown@wfubmc.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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