| pubmed-article:14970869 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14970869 | lifeskim:mentions | umls-concept:C0014852 | lld:lifeskim |
| pubmed-article:14970869 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:14970869 | lifeskim:mentions | umls-concept:C1424448 | lld:lifeskim |
| pubmed-article:14970869 | lifeskim:mentions | umls-concept:C0596263 | lld:lifeskim |
| pubmed-article:14970869 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:14970869 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:14970869 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:14970869 | pubmed:dateCreated | 2004-2-18 | lld:pubmed |
| pubmed-article:14970869 | pubmed:abstractText | In response to DNA damage, the cell cycle checkpoint kinase 2 (CHEK2) may phosphorylate p53, Cdc25A and Cdc25C, and regulate BRCA1 function, leading to cell cycle arrest and DNA repair. The truncating germline mutation CHEK2(*)1100delC abrogates kinase activity and confers low-penetrance susceptibility to breast cancer. We found CHEK2(*)1100delC in 0.5% of 190 oesophageal squamous cell carcinomas and in 1.5% of 196 oesophageal adenocarcinomas. In addition, we observed the mutation in 3.0% of 99 Barrett's metaplasias and 1.5% of 66 dysplastic Barrett's epithelia, both known precursor lesions of oesophageal adenocarcinoma. Since CHEK2(*)1100delC mutation frequencies did not significantly differ among oesophageal squamous cell carcinomas, adenocarcinomas and (dysplastic) Barrett's epithelia, as compared to healthy individuals, we conclude that the CHEK2(*)1100delC mutation has no major contribution in oesophageal carcinogenesis. | lld:pubmed |
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| pubmed-article:14970869 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14970869 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14970869 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14970869 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14970869 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:14970869 | pubmed:author | pubmed-author:TilanusH WHW | lld:pubmed |
| pubmed-article:14970869 | pubmed:author | pubmed-author:SchutteMM | lld:pubmed |
| pubmed-article:14970869 | pubmed:author | pubmed-author:AbbotLL | lld:pubmed |
| pubmed-article:14970869 | pubmed:author | pubmed-author:DinjensW N... | lld:pubmed |
| pubmed-article:14970869 | pubmed:author | pubmed-author:KoppertL BLB | lld:pubmed |
| pubmed-article:14970869 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14970869 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:14970869 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:14970869 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14970869 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14970869 | pubmed:pagination | 888-91 | lld:pubmed |
| pubmed-article:14970869 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:14970869 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14970869 | pubmed:articleTitle | The CHEK2(*)1100delC mutation has no major contribution in oesophageal carcinogenesis. | lld:pubmed |
| pubmed-article:14970869 | pubmed:affiliation | Department of Pathology, Erasmus university Medical Center, Josephine Nefkens Institute, PO Box 1738, Rotterdam 3000 DR, The Netherlands. | lld:pubmed |
| pubmed-article:14970869 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:11200 | entrezgene:pubmed | pubmed-article:14970869 | lld:entrezgene |
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