Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-2-18
pubmed:abstractText
In response to DNA damage, the cell cycle checkpoint kinase 2 (CHEK2) may phosphorylate p53, Cdc25A and Cdc25C, and regulate BRCA1 function, leading to cell cycle arrest and DNA repair. The truncating germline mutation CHEK2(*)1100delC abrogates kinase activity and confers low-penetrance susceptibility to breast cancer. We found CHEK2(*)1100delC in 0.5% of 190 oesophageal squamous cell carcinomas and in 1.5% of 196 oesophageal adenocarcinomas. In addition, we observed the mutation in 3.0% of 99 Barrett's metaplasias and 1.5% of 66 dysplastic Barrett's epithelia, both known precursor lesions of oesophageal adenocarcinoma. Since CHEK2(*)1100delC mutation frequencies did not significantly differ among oesophageal squamous cell carcinomas, adenocarcinomas and (dysplastic) Barrett's epithelia, as compared to healthy individuals, we conclude that the CHEK2(*)1100delC mutation has no major contribution in oesophageal carcinogenesis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-10233832, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-10435585, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-10617473, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-10767643, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-10987268, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11011113, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11053450, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11100718, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11224619, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11248330, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11431331, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11593395, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11699418, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11719428, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11733767, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11746983, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11793476, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11949635, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-11967536, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-12052256, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-12081731, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-12094328, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-12363465, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-1467771, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-1868473, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-2874485, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-8194706, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-9665490, http://linkedlifedata.com/resource/pubmed/commentcorrection/14970869-9836640
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
888-91
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
The CHEK2(*)1100delC mutation has no major contribution in oesophageal carcinogenesis.
pubmed:affiliation
Department of Pathology, Erasmus university Medical Center, Josephine Nefkens Institute, PO Box 1738, Rotterdam 3000 DR, The Netherlands.
pubmed:publicationType
Journal Article