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pubmed:abstractText |
Insulin-responsive adipogenic signaling molecules include insulin receptor substrates (IRS)-1 and -2, phosphoinositide 3-kinase (PI3K), and protein kinase B (PKB; also known as Akt). Mammalian target of rapamycin (mTOR) is a PKB substrate, and regulates p70 S6 kinase (p70 S6K). Since p70 S6K is an insulin-responsive kinase downstream of PI3K and PKB, its potential role in adipogenic insulin signaling was investigated.
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pubmed:affiliation |
Department of Medicine and Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa Health Research Institute, Ottawa, Canada K1Y 4E9.
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