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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-2-18
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pubmed:abstractText |
Cyclooxygenase-2 (COX-2), an inducible isoform of cyclooxygenase, is overexpressed in many types of malignant tumors, which in turn may stimulate tumor growth and protect against damage by irradiation or cytotoxic agents. The purpose of this study is to investigate the relationship between the radiation sensitivity and elevated level of COX-2. Radiation sensitivity of the eight oral SCC cell lines differed greatly in their response to radiation. Further, the level of the COX-2 expression correlated inversely with increased tumor radiation sensitivity. The similar significant association between the response to preoperative radiation therapy and COX-2 overexpression was observed in the oral SCC patients. In addition, treatment with a COX-2 selective inhibitor enhanced the radioresponse of HSC-2 cell, which constitutively expressed COX-2. These results suggested that COX-2 expression level correlates to radiation tolerance and the COX-2 selective inhibitor may be a potent enhancer for tumor radioresponse in oral SCC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/celecoxib
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1368-8375
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
383-9
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:14969817-Adult,
pubmed-meshheading:14969817-Aged,
pubmed-meshheading:14969817-Aged, 80 and over,
pubmed-meshheading:14969817-Antineoplastic Agents,
pubmed-meshheading:14969817-Carcinoma, Squamous Cell,
pubmed-meshheading:14969817-Cell Survival,
pubmed-meshheading:14969817-Cyclooxygenase 2,
pubmed-meshheading:14969817-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:14969817-Cyclooxygenase Inhibitors,
pubmed-meshheading:14969817-Dose-Response Relationship, Radiation,
pubmed-meshheading:14969817-Female,
pubmed-meshheading:14969817-Humans,
pubmed-meshheading:14969817-Isoenzymes,
pubmed-meshheading:14969817-Male,
pubmed-meshheading:14969817-Membrane Proteins,
pubmed-meshheading:14969817-Middle Aged,
pubmed-meshheading:14969817-Mouth Neoplasms,
pubmed-meshheading:14969817-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:14969817-Pyrazoles,
pubmed-meshheading:14969817-Radiation Tolerance,
pubmed-meshheading:14969817-Sulfonamides,
pubmed-meshheading:14969817-Tumor Cells, Cultured,
pubmed-meshheading:14969817-Tumor Markers, Biological
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pubmed:year |
2004
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pubmed:articleTitle |
Overexpression of cyclooxygenase-2 is associated with radioresistance in oral squamous cell carcinoma.
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pubmed:affiliation |
Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan. terakado@m.ehime-u.ac.jp
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pubmed:publicationType |
Journal Article
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