|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2004-2-18
|
|
pubmed:abstractText |
The acute phase response is the major adverse effect of intravenously administered N-BPs. In this study we show that N-BPs cause gamma,delta-T-cell activation and proliferation in vitro by an indirect mechanism through inhibition of FPP synthase, an effect that can be overcome by inhibiting HMG-CoA reductase with a statin. These studies clarify the probable initial cause of the acute phase response to N-BP drugs and suggest a possible way of preventing this phenomenon.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0884-0431
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
278-88
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:14969398-Alkyl and Aryl Transferases,
pubmed-meshheading:14969398-Cell Division,
pubmed-meshheading:14969398-Diphosphonates,
pubmed-meshheading:14969398-Geranyltranstransferase,
pubmed-meshheading:14969398-Humans,
pubmed-meshheading:14969398-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:14969398-Lymphocyte Activation,
pubmed-meshheading:14969398-Mevalonic Acid,
pubmed-meshheading:14969398-Protein Prenylation,
pubmed-meshheading:14969398-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:14969398-T-Lymphocytes
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro.
|
|
pubmed:affiliation |
Bone Research Group, Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom. k.thompson@abdn.ac.uk
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
