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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-2-17
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pubmed:abstractText |
The present study aimed at characterizing the epitopes recognized by coxsackievirus B4 (CBV4)-specific T-cell lines established from 23 children with type 1 diabetes (T1D) and 29 healthy children with T1D risk-associated HLA genotypes. Responsiveness to VP1 region was dependent on the specific infection history as 55% of the T-cell lines from donors with neutralizing antibodies to CBV serotypes responded to VP1 peptides compared to none of the T-cell lines from other donors (P = 0.01). The pattern of recognized peptides was dependent of the HLA genotype. Forty-two percent of the T-cell lines from donors carrying the HLA-(DR4)-DQB1*0302 haplotype responded to VP1 peptides 71-80 compared to none of the T-cell lines from donors without this haplotype (P = 0.02). No evidence for the existence of diabetes-specific epitopes was found. Only few epitopes were exclusive recognized by T cells from diabetic children, and in each case only one or two T-cell lines were responding.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
319
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-35
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14967485-Adolescent,
pubmed-meshheading:14967485-Amino Acid Sequence,
pubmed-meshheading:14967485-Antibodies, Viral,
pubmed-meshheading:14967485-Antigens, Viral,
pubmed-meshheading:14967485-Cell Line,
pubmed-meshheading:14967485-Child,
pubmed-meshheading:14967485-Child, Preschool,
pubmed-meshheading:14967485-Diabetes Mellitus, Type 1,
pubmed-meshheading:14967485-Enterovirus B, Human,
pubmed-meshheading:14967485-Enterovirus Infections,
pubmed-meshheading:14967485-Epitopes, T-Lymphocyte,
pubmed-meshheading:14967485-Genotype,
pubmed-meshheading:14967485-HLA-DQ Antigens,
pubmed-meshheading:14967485-HLA-DR Antigens,
pubmed-meshheading:14967485-Haplotypes,
pubmed-meshheading:14967485-Humans,
pubmed-meshheading:14967485-Lymphocyte Activation,
pubmed-meshheading:14967485-Molecular Sequence Data,
pubmed-meshheading:14967485-T-Lymphocytes,
pubmed-meshheading:14967485-Tissue Donors
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pubmed:year |
2004
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pubmed:articleTitle |
Epitopes recognized by CBV4 responding T cells: effect of type 1 diabetes and associated HLA-DR-DQ haplotypes.
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pubmed:affiliation |
JDRF Center for Preevention of Type 1 Diabetes in Finland, Finland. jane.marttila@utu.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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