pubmed-article:14966368 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:14966368 | lifeskim:mentions | umls-concept:C0001302 | lld:lifeskim |
pubmed-article:14966368 | lifeskim:mentions | umls-concept:C0013794 | lld:lifeskim |
pubmed-article:14966368 | lifeskim:mentions | umls-concept:C0002771 | lld:lifeskim |
pubmed-article:14966368 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:14966368 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
pubmed-article:14966368 | lifeskim:mentions | umls-concept:C0205099 | lld:lifeskim |
pubmed-article:14966368 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:14966368 | pubmed:dateCreated | 2004-2-17 | lld:pubmed |
pubmed-article:14966368 | pubmed:abstractText | Evidence in the past decade indicates that the mechanisms of anti-nociception of electroacupuncture (EAc) involve actions of neuropeptides (i.e., enkephalin and endorphin) and monoamines (i.e., serotonin and norepinephrine) in the central nervous system. Our present results using a subcutaneous injection of formalin to test pain sensation in mice provide further understanding of the involvement of serotonin in the actions of EAc-induced analgesia. Our observations show that (1) EAc at three different frequencies (2, 10 and 100 Hz) elicited an anti-nociceptive effect as determined by behavioral observations of reduced hindpaw licking; (2) exogenously intracerebroventricular administration of 5-hydroxytryptamine (5-HT) exhibited an analgesic effect, which partially mimicked the analgesic actions of EAc; (3) the anti-nociception of EAc at different frequencies was attenuated after reduced biosynthesis of serotonin by the administration of the tryptophan hydroxylase inhibitor, P-chlorophenylalanine, and (4) the 5-HT(1A) and 5-HT(3) receptor antagonists, pindobind-5-HT(1A) and LY-278584, respectively, blocked three different frequencies of EAc-induced analgesic effects, but the anti-nociceptive effect of 100 Hz EAc was potentiated by the 5-HT(2) receptor antagonist, ketanserin. These observations suggest that 5-HT(1A) and 5-HT(3) receptors partially mediate the analgesic effects of EAc, but that the 5-HT(2) receptor is conversely involved in the nociceptive response. | lld:pubmed |
pubmed-article:14966368 | pubmed:language | eng | lld:pubmed |
pubmed-article:14966368 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14966368 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:14966368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14966368 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:14966368 | pubmed:issn | 1021-7770 | lld:pubmed |
pubmed-article:14966368 | pubmed:author | pubmed-author:LinJaung-Geng... | lld:pubmed |
pubmed-article:14966368 | pubmed:author | pubmed-author:ChangFang-Chi... | lld:pubmed |
pubmed-article:14966368 | pubmed:author | pubmed-author:TsaiHuei-Yann... | lld:pubmed |
pubmed-article:14966368 | pubmed:author | pubmed-author:YuMing-ChienM... | lld:pubmed |
pubmed-article:14966368 | pubmed:author | pubmed-author:YiPei-LuPL | lld:pubmed |
pubmed-article:14966368 | pubmed:copyrightInfo | Copyright 2004 National Science Council, ROC and S. Karger AG, Basel | lld:pubmed |
pubmed-article:14966368 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:14966368 | pubmed:volume | 11 | lld:pubmed |
pubmed-article:14966368 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:14966368 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:14966368 | pubmed:pagination | 179-85 | lld:pubmed |
pubmed-article:14966368 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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pubmed-article:14966368 | pubmed:articleTitle | The central serotonergic system mediates the analgesic effect of electroacupuncture on ZUSANLI (ST36) acupoints. | lld:pubmed |
pubmed-article:14966368 | pubmed:affiliation | Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, Taiwan/ROC. | lld:pubmed |
pubmed-article:14966368 | pubmed:publicationType | Journal Article | lld:pubmed |
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