Source:http://linkedlifedata.com/resource/pubmed/id/14966368
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2004-2-17
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pubmed:abstractText |
Evidence in the past decade indicates that the mechanisms of anti-nociception of electroacupuncture (EAc) involve actions of neuropeptides (i.e., enkephalin and endorphin) and monoamines (i.e., serotonin and norepinephrine) in the central nervous system. Our present results using a subcutaneous injection of formalin to test pain sensation in mice provide further understanding of the involvement of serotonin in the actions of EAc-induced analgesia. Our observations show that (1) EAc at three different frequencies (2, 10 and 100 Hz) elicited an anti-nociceptive effect as determined by behavioral observations of reduced hindpaw licking; (2) exogenously intracerebroventricular administration of 5-hydroxytryptamine (5-HT) exhibited an analgesic effect, which partially mimicked the analgesic actions of EAc; (3) the anti-nociception of EAc at different frequencies was attenuated after reduced biosynthesis of serotonin by the administration of the tryptophan hydroxylase inhibitor, P-chlorophenylalanine, and (4) the 5-HT(1A) and 5-HT(3) receptor antagonists, pindobind-5-HT(1A) and LY-278584, respectively, blocked three different frequencies of EAc-induced analgesic effects, but the anti-nociceptive effect of 100 Hz EAc was potentiated by the 5-HT(2) receptor antagonist, ketanserin. These observations suggest that 5-HT(1A) and 5-HT(3) receptors partially mediate the analgesic effects of EAc, but that the 5-HT(2) receptor is conversely involved in the nociceptive response.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Formaldehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT3,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists
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pubmed:status |
MEDLINE
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pubmed:issn |
1021-7770
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2004 National Science Council, ROC and S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-85
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14966368-Acupuncture Analgesia,
pubmed-meshheading:14966368-Acupuncture Points,
pubmed-meshheading:14966368-Animals,
pubmed-meshheading:14966368-Electroacupuncture,
pubmed-meshheading:14966368-Formaldehyde,
pubmed-meshheading:14966368-Male,
pubmed-meshheading:14966368-Mice,
pubmed-meshheading:14966368-Mice, Inbred ICR,
pubmed-meshheading:14966368-Pain,
pubmed-meshheading:14966368-Pain Measurement,
pubmed-meshheading:14966368-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:14966368-Receptors, Serotonin, 5-HT2,
pubmed-meshheading:14966368-Receptors, Serotonin, 5-HT3,
pubmed-meshheading:14966368-Serotonin,
pubmed-meshheading:14966368-Serotonin Antagonists,
pubmed-meshheading:14966368-Serotonin Receptor Agonists
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pubmed:articleTitle |
The central serotonergic system mediates the analgesic effect of electroacupuncture on ZUSANLI (ST36) acupoints.
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pubmed:affiliation |
Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, Taiwan/ROC.
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pubmed:publicationType |
Journal Article
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