|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2004-2-17
|
|
pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY459335,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY459336,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY459337,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY459338,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY459339,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY459340,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY459341,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY459342,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY459343,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY459344,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY459345
|
|
pubmed:abstractText |
The molecular evolution of the R2R3-MYB gene family is of great interest because it is one of the most important transcription factor gene families in the plant kingdom. Comparative analyses of a gene family may reveal important adaptive changes at the protein level and thereby provide insights that relate structure to function. We have performed a range of comparative and bioinformatics analyses on R2R3-MYB genes identified from the rice (Oryza sativa subsp. japonica and indica) and Arabidopsis genome sequences. The study provides an initial framework to investigate how different evolutionary lineages in a gene family evolve new functions. Our results reveal a remarkable excess of non-synonymous substitutions, an indication of adaptive selection on protein structure that occurred during the evolution of both helix1 and helix2 of rice R2R3-MYB DNA-binding domains. These flexible alpha-helix regions associated with high frequencies of excess non-synonymous substitutions may play critical roles in the characteristic packing of R2R3-MYB DNA-binding domains and thereby modify the protein-DNA interaction process resulting in the recognition of novel DNA-binding sites. Furthermore, a co-evolutionary pattern is found between the second alpha-helix of the R2 domain and the second alpha-helix of the R3 domain by examining all the possible alpha-helix pairings in both the R2 and R3 domains. This points to the functional importance of pairing interactions between related secondary structures.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-10198085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-10390345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-10395796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-10482656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-10490023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-10556506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-10645718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-10712951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-10743663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-10833261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-10860738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-10899976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11073452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11166654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11231894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11244096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11264415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11290293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11310740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11335019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11377959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11549766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11597504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11682313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11779548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11845200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11935009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11935017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-11935018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-12415313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-12447438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-12447439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-12519988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-12869764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-1594446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-1887237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-2236054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-2762323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-6599963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-7682012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-7705642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-7851788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-7896112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-7954830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-7984417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-8145825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-8193955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-8312738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-8535141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-8676743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-8710361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-8990116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-8995298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9055608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9150608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9281423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9353194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9367129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9370307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9402743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9419235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9520431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9539414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9541535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9543002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9628022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9668128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9839469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14966247-9853753
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
