Linked Life Data

14965164

Source:http://linkedlifedata.com/resource/pubmed/id/14965164

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-2-13
pubmed:abstractText
Possible in vitro inhibition of aromatic amino acid decarboxylase (AAD, EC 4.1.1.28) by a group of phenylsulfonylbenzoic acid derivatives VUFB 19363, 19369, 19370, 19371, and 19760 as new potential anti-inflammatory compounds was studied using the substrate L-tyrosine. Enzyme inhibition by 2.7 x 10(-5) M concentration of compound VUFB 19363 (Quinlukast) was 17%, AAD inhibition at 3.75 x 10(-5) M concentration of compounds VUFB 19369, 19370, 19371, and 19760 ranged between 9-23%. There were distinct differences between individual compounds. Evaluation of inhibition kinetics suggested full reversibility with VUFB 19369 and the uncompetitive type of inhibition in the case of compound VUFB 19363. Considering the anti-inflammatory activity of the compounds studied, the weak AAD inhibition found is rather favourable for their prospective pharmacological effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1211-4286
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-51
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Inhibition of aromatic amino acid decarboxylase by a group of new potential nonsteroidal anti-inflammatory drugs with antileukotrienic effects.
pubmed:affiliation
Charles University in Prague, Faculty of Pharmacy in Hradec Králové: Department of Biochemical Sciences and Research Centre LN00B125, Czech Republic. drsata@faf.cuni.cz
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't