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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-2-13
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pubmed:abstractText |
We investigated how the broadly neutralizing monoclonal antibody 2F5 affects the human immunodeficiency virus type 1 envelope glycoprotein as it undergoes receptor-induced conformational changes and show that 2F5 binds both native and fusion-intermediate conformations, suggesting inhibition of a late step in virus entry. We also demonstrate conformational changes in the C heptad of gp41.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-10581440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-10846104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-10933713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-11027678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-11229405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-11507232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-11583156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-11602729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-11602730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-11788027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-11803079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-12072535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-12237296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-12379111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-12414953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-12525600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-12631714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-12641452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-12805467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-12860131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-1438243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-7512157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-7530400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-7576928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-7692082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-7888224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-8230430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-8312047,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-8500173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-9060620,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-9439994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-9444991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-9546217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-9630213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-9811701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963170-9811763
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2627-31
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:14963170-Antibodies, Monoclonal,
pubmed-meshheading:14963170-Antibody Specificity,
pubmed-meshheading:14963170-Antigens, CD4,
pubmed-meshheading:14963170-Epitopes,
pubmed-meshheading:14963170-HIV Envelope Protein gp41,
pubmed-meshheading:14963170-HIV-1,
pubmed-meshheading:14963170-Membrane Fusion,
pubmed-meshheading:14963170-Neutralization Tests,
pubmed-meshheading:14963170-Protein Conformation,
pubmed-meshheading:14963170-Solubility
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pubmed:year |
2004
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pubmed:articleTitle |
Binding of the 2F5 monoclonal antibody to native and fusion-intermediate forms of human immunodeficiency virus type 1 gp41: implications for fusion-inducing conformational changes.
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pubmed:affiliation |
Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 20892-4555, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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