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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-2-13
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pubmed:abstractText |
Regulatory T (T(R)) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4(+) CD25(+) human T(R) cells suppress virus-specific T-cell responses. Depletion of T(R) cells from peripheral blood mononuclear cells enhances T-cell responses to cytomegalovirus and human immunodeficiency virus antigens. We propose that chronic viral infections lead to induction of suppressive T(R) cells that inhibit the antiviral immune response.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-10228007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-10395840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-10549628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-10605010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-10837065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-10850488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11067871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11238621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11276200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11298351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11390435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11390437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11390478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11459933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11466340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11675346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11801641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11859115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-11970966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-12466842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-12658273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-12734345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-12975455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-2974045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-7636184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-7876598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-8760792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-9338786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14963140-9620592
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2454-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:14963140-Antigens, Viral,
pubmed-meshheading:14963140-CD4-Positive T-Lymphocytes,
pubmed-meshheading:14963140-CD8-Positive T-Lymphocytes,
pubmed-meshheading:14963140-Cells, Cultured,
pubmed-meshheading:14963140-Cytomegalovirus,
pubmed-meshheading:14963140-Flow Cytometry,
pubmed-meshheading:14963140-HIV,
pubmed-meshheading:14963140-Humans,
pubmed-meshheading:14963140-Interferon-gamma,
pubmed-meshheading:14963140-Lymphocyte Activation,
pubmed-meshheading:14963140-Receptors, Interleukin-2,
pubmed-meshheading:14963140-Superantigens
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pubmed:year |
2004
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pubmed:articleTitle |
Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens.
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pubmed:affiliation |
Gladstone Institute of Virology and Immunology, University of California-San Francisco, San Francisco, California 94110, USA. aandahl@basalmed.uio.no
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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