Linked Life Data

14962195

Source:http://linkedlifedata.com/resource/pubmed/id/14962195

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-2-13
pubmed:abstractText
In man and in mouse, B-cell maturation occurs in steps, first in the bone marrow from hematopoietic precursors to immature/transitional B cells, then in the periphery from transitional to fully mature B cells. Each developmental step is tightly controlled by the expression and function of the B-cell receptor (BCR) and by the ability to interact with the microenvironment. Mature B cells collaborate with T cells in the adaptive immune response, leading to the production of high-affinity antibodies. This response is very accurate, but slow. Immediately after pathogen entry, however, antibodies already present in the serum reinforce the innate immune response and contribute to the first-line defense against infection. Low-affinity natural antibodies are produced by B-1a B cells in the mouse and immunoglobulin M (IgM) memory cells in man. These antibodies represent an immediate protection against all microorganisms and the only one against encapsulated bacteria. B-1a and IgM memory B cells may function as a link between the innate and adaptive immune response and thus perform a primordial B-cell function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0105-2896
pubmed:author
pubmed:issnType
Print
pubmed:volume
197
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-91
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Peripheral development of B cells in mouse and man.
pubmed:affiliation
Research Center Ospedale Bambino Gesù, Roma, Italy. rita.carsetti@uniroma2.it
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't